Clinical Characteristics of Lymphatic Malformations: An Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 320
- 试验地点
- 1
- 主要终点
- The location of abdominal lymphatic malformations in participants
研究概览
简要总结
The primary purpose of this study is to retrospectively identify the clinical characteristics of abdominal lymphatic malformations (ALMs) in our single center in China. The second objective of this study is to retrospectively compare the epidemiological features, clinical presentations, cyst properties, surgical treatments, and risk factors for preoperative complications of ALMs between paediatric participants and adult participants.
详细描述
Lymphatic malformations (LMs) are vascular anomalies that arise from abnormal embryonic development of the lymphatic system and can present as dilated lymphatic channels or cysts lined by lymphatic endothelial cells. Abdominal lymphatic malformations (ALMs) are rare entities that account for fewer than 10% of LMs and may occur not only in the tissues or organs in the abdominal cavity, such as the mesentery, spleen and pancreas but also in the retroperitoneal space. ALMs can manifest as an infection, chronic abdominal discomfort, acute abdomen, or fatal disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The investigators enrolled participants who were pathologically diagnosed with lymphangioma or lymphatic malformations in the abdominal cavity (i.e., abdominal lymphatic malformations) from January 2009 to December 2022 at our institution.
排除标准
- •The investigators excluded participants without a pathological diagnosis of abdominal lymphatic malformations through resection specimens and those with pathological confirmation of other diseases, as well as patients with complex lymphatic anomalies.
结局指标
主要结局
The location of abdominal lymphatic malformations in participants
时间窗: From 2009.1 to 2022.12
Location included mesentery, retroperitoneum, omentum, spleen, etc.
The morphologic subtypes of abdominal lymphatic malformations in participants
时间窗: From 2009.1 to 2022.12
Morphologic subtypes included macrocystic, microcystic and mixed type.
The presentations at diagnosis of abdominal lymphatic malformations in participants
时间窗: From 2009.1 to 2022.12
Presentations at diagnosis included chronic pain, acute abdominal disease and incidental health checkup.
The largest diameter of abdominal lymphatic malformations in participants
时间窗: From 2009.1 to 2022.12
Largest diameter in centimeters was mainly measured by intraoperative detections.
The preoperative complications of abdominal lymphatic malformations in participants
时间窗: From 2009.1 to 2022.12
Preoperative complications included intestinal volvulus, haemorrhage, infection, rupture and compression.
次要结局
- The rate of abdominal lymphatic malformations located in mesentery for paediatric and adult group(From 2009.1 to 2022.12)
- The incidence of abdominal lymphatic malformations in paediatric and adult group(From 2009.1 to 2022.12)
- The number of female patients with abdominal lymphatic malformations in paediatric and adult group(From 2009.1 to 2022.12)
- The rate of abdominal lymphatic malformations with acute abdomen in paediatric and adult group(From 2009.1 to 2022.12)
- The risk factors of preoperative complications of abdominal lymphatic malformations for paediatric and adult group.(From 2009.1 to 2022.12)
研究者
Yi Ji
Principal Investigator
West China Hospital