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临床试验/NCT03694665
NCT03694665已完成不适用

Non-invasive Assessment of Lung Recruitment in Morbid Obese Patients Undergoing Bariatric Surgery

Hospital Privado de Comunidad de Mar del Plata2 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2016年9月11日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
30
试验地点
2
主要终点
Measurement of the optimum positive end-expiratory pressure in anesthetized morbidly obese patients

研究概览

简要总结

Morbid obese patients present changes in respiratory physiology caused by weight overload. Intraoperative atelectasis is a pulmonary complication that affects not only gas exchange but also respiratory mechanics. The present study was aimed to test the role of different parameters for monitoring the treatment of atelectasis by a lung recruitment maneuver.

详细描述

This is a prospective study perform in 30 anesthetized morbidly obese undergoing bariatric surgery. Lung mechanics and volumetric capnography will be non-invasively assessed during laparoscopy. Esophageal pressure will be measured by an esophageal balloon to measure transpulmonary pressure. A lung recruitment maneuver will be done. The optimum level of positive end-expiratory pressure (PEEP) is defined as the PEEP level when transpulmonary pressure remains positive during the PEEP titration trial of the recruitment maneuver. Lung collapse is detected when transpulmonary pressure becomes negative. The behavior of the studied volumetric capnography and lung mechanics parameters will be compared with the reference transpulmonary pressure signal.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Diagnostic
盲法
None

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Body mass index (BMI) > 40 kg/m2
  • Written inform consent
  • Scheduled for bariatric surgery
  • American Society of Anesthesia physical status II-III

排除标准

  • Acute pulmonary disease
  • Emergency surgery

研究组 & 干预措施

Morbidly anesthetized obese

Other

Morbidly obese patients undergoing bariatric surgery (single-arm study) will receive a Lung recruitment maneuver to treat atelectasis..

干预措施: Lung recruitment maneuver (Other)

结局指标

主要结局

Measurement of the optimum positive end-expiratory pressure in anesthetized morbidly obese patients

时间窗: intraoperative

Comparison between a reference method (esophageal balloon) with volumetric capnography.

次要结局

未报告次要终点

研究者

发起方
Hospital Privado de Comunidad de Mar del Plata
申办方类型
Other
责任方
Sponsor

研究点 (2)

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