Ex vivo experiments to evaluate the role of medication on the colon permeability in microscopic colitis - The role of medication on the colon permeability in MC

Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 13 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

暂无简介。

•In general: aged between 50-75 years, no current use of NSAIDs, PPIs or SSRIs.
•* For patients in remission: positive diagnosis of microscopic, in remission under medication
•* For patients with active disease: positive diagnosis of microscopic, collagenous or lymphocytic colitis; confirmed active disease due to relapse, no recent treatment for MC
•* For healthy controls: no prior positive diagnosis of microscopic, collagenous or lymphocytic colitis.

•- Age below 18 years at the time of diagnosis
•- Use of anticoagulants or immunosuppressive drugs
•- Severe co-morbidities (including cardiopulmonary disease, portal hypertension, collagen diseases, morbid obesity, coagulation disorders and any co-morbidity hindering an endoscopic procedure)
•- A previous history of any type of chronic colitis (other than MC), irritable bowel syndrome, colon carcinoma or (partial) colectomy
•- A recent (last year) diagnosis of infectious diarrhea or radiation proctitis.
•- Use of medication known for influencing intestinal permeability
•- Excessive alcohol usage (>20 standard units per week)
•- Not capable of signing an informed consent
•- Defaecation diary is not matching the predefined stool frequency for the designated patient group (active, remission, control)

发起方

Medisch Universitair Ziekenhuis Maastricht