White Matter Plasticity in Schizophrenia
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- White matter microstructure
研究概览
简要总结
Schizophrenia spectrum disorders are associated with impairment in the microstructure of white matter, the key brain tissue responsible for fast communication between different brain regions necessary for any complex task. This white matter impairment is linked to problems with cognition in schizophrenia, especially slower processing speed. This project aims to study the potential for correcting white matter deficits in schizophrenia by examining mechanisms underlying white matter structure changes in response to training on playing a mock musical instrument.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 15 Years 至 45 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, or psychosis NOS
- •age 15-45
- •able to provide informed consent
排除标准
- •contraindications to MRI (metal implants, claustrophobia)
- •medical condition that limits use of hands (ie, arthritis)
- •Active or recent (within 6 months) substance use disorder other than nicotine
研究组 & 干预措施
Active training
Training sessions involving playing the video game 'Guitar Hero'
干预措施: Music video game (Behavioral)
Observation training
干预措施: Music video game (Behavioral)
结局指标
主要结局
White matter microstructure
时间窗: 3 weeks
fractional anisotropy of white matter tracts as assessed with diffusion tensor imaging
次要结局
- Brain level of N-acetylaspartate(3 weeks)