NCT02678884招募中不适用
A Pilot Study of 18F-FDG PET-CT Kinetic Analysis in Head and Neck Squamous Cell Carcinoma (HNSCC)
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Measure rate constant of 18F-FDG uptake in tumour and normal tissue with dynamic PET scanning before radiotherapy.
研究概览
简要总结
The purpose of this study is to see how useful the information provided from Positron Emission Tomography (PET) scans can be in the actual planning and delivery of radiation treatment to patients who have head and neck cancers. Patients participating in this study, will have (in addition to their routine tests) a PET scan before and during their radiation treatment. Following the intervention, patients will be followed as per standard practice.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Non-nasopharynx head and neck mucosal squamous cell carcinoma
- •Radiologically evident gross disease
- •Radiotherapy alone for curative intent
- •Age equal to or more than 18 years old
- •To be eligible for the second study PET-CT scan: FDG avid tumour (or minimum SUV of 2.5) on the first study PET-CT scan
排除标准
- •Nasopharynx cancer
- •H&N SCC skin
- •Distant metastases (already known or if found on baseline CT-thorax)
- •Prior malignancy within the last 5 years (exclude non-H&N SCC, BCC skin)
- •Prior chemotherapy within the last 5 years or concurrent chemotherapy/EGFR inhibitors
- •Prior head and neck radiotherapy
- •Inability to lie supine for study duration
- •Pregnancy
- •Inability to provide informed consent
研究组 & 干预措施
HNSCC Patients receiving RT
Experimental
干预措施: 18-F FDG (Drug)
结局指标
主要结局
Measure rate constant of 18F-FDG uptake in tumour and normal tissue with dynamic PET scanning before radiotherapy.
时间窗: ~ 2 years
次要结局
- Measure rate constant of 18F-FDG uptake in tumour and inflammatory tissue with dynamic PET scanning during radiotherapy .(~ 2 years)
研究者
研究点 (1)
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