Dysregulated Urea-synthesis at Terminal Uremia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Urea synthesis rate during alanine infusion
研究概览
简要总结
This project will examine the dysregulation of the urea cycle in patients with terminal uremia using a validated method named "Functional Hepatic Nitrogen Clearance"
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age > or equal to 18 years
- •Chronic hemodialysis during 3 months
- •Patients with functioning arteriovenous-fistula assigned to "Center-Hemodialysis" at "Nyresygdomme, AUH Skejby"
排除标准
- •Active infection
- •Conditions with vomiting or diarrhea
- •Active disease being treated with chemotherapy, radiationtherapy, biologic- or similar treatments. Disease under observation can be included.
- •Liver disease
- •Vessels on the upper extremities not suited for cannulation
- •Prednisolone treatment during the last 8 weeks
- •Pregnancy
- •BMI > or equal to 30 or < or equal to 18
- •Physically or mentally condition that does not allow the project to be completed
- •Language-difficulties that does not allow the project to be completed
研究组 & 干预措施
Alanine-infusion
Alanine infusion taking place over a 3 hour period while monitorering metabolic changes in blood samples before and after dialysis
干预措施: Aminoacid, alanine-infusion (Other)
结局指标
主要结局
Urea synthesis rate during alanine infusion
时间窗: 4 hours. 1 hour of blood sample measuring of baseline urea-synthesis rate and 3 hours of urea-synthesis rate during alanine-infusion
Change in the synthesis of urea during a 3 hour period of alanine-infusion in pre and post hemodialysis patients. We will use a validated method named functional hepatic nitrogen clearance (FHNC) to evaluate the synthesis of urea. FHNC is calculated using the linear relation between urea nitrogen synthesis rate and blood-amino acid which is measured every hour. An estimated group of 10 dialysis patients will be included and compared to a clinical healthy group. The healthy group has also received alanine infusion and blood samples of urea and amino-acids has likewise been measured for every hour of infusion.
次要结局
未报告次要终点