Therapeutic Follow-up of Antibiotics in Pediatric Intensive Care
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 280
- 试验地点
- 1
- 主要终点
- The occurrence of at least one "underdosing" event of one of the Antibiotics used in a patient included during his or her hospitalization in pediatrics intensive care unit (PICU)
研究概览
简要总结
Currently, recommendations for antibiotic testing (ATS) in adult intensive care have been published. The 2018 SFAR and the Abdul- Aziz et al expert conference recommend routine testing for β-lactams, aminoglycosides, linezolid, and vancomycin and provide plasma concentration goals. No recommendations have been made for the pediatric intensive care unit (PICU) population. However, several articles report suboptimal plasma concentrations for the most frequently used antibiotics in PICU. The University Hospital of Reunion is the reference center for the western region of the Indian Ocean. This region presents a large mixed population due to the migratory flow, as well as a specific bacterial ecology. This suggests that the data already collected on antibiotic dosage in other European studies may not be fully extrapolated to Reunion Island.
It is in this context that we will study the plasma concentration of antibiotics for all children who received the most commonly used antibiotics (β-lactams, linezolid, vancomycin, and aminoglycosides) during their hospitalization in PICU.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any child hospitalized in the pediatric intensive care unit of the CHU Nord de La Réunion,
- •Age is less than 18 years,
- •Having started a curative antibiotic therapy by β-lactam, linezolid, vancomycin or aminosides.
- •For whom a non-opposition has been collected orally from both or one of the child's legal guardians and from the child himself (if applicable),
- •Covered by Social Security.
排除标准
- •Patients on prophylactic antibiotic therapy
结局指标
主要结局
The occurrence of at least one "underdosing" event of one of the Antibiotics used in a patient included during his or her hospitalization in pediatrics intensive care unit (PICU)
时间窗: 2 months
Underdosing is defined as a measurement of plasma concentration below the optimal therapeutic concentration (OTC)
次要结局
未报告次要终点