Ridge Preservation Using Guided Regenaration, Platelet-rich Plasma and Free Gingival Grafts
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- Vertical post-extraction resorption of the socket walls
研究概览
简要总结
The goal of this clinical trial is to learn if ridge preservation methods with dense polytetrafluoroethylene membranes, with d-PTFE membranes and platelet-rich plasma, and with free gingival grafts can reduce vertical resorption of the post-extraction socket walls.
Researchers compared each experimental group to a control group (unassisted socket healing). Participants were randomly allocated to one of the four groups.
Cone-beam computed tomography was performed after the procedure and 3 months post-operatively to evaluate the vertical socket wall resorption.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients in the age group 18-65 years;
- •Patients in good general condition;
- •Patients requiring extraction of premolars or molars;
- •Patients in whom restoration of the missing tooth with a dental implant and/or prosthetic construction is planned;
- •Signed informed consent to participate in the study.
排除标准
- •Patients with contraindications for general surgical treatment:
- •patients with uncontrolled arterial hypertension;
- •patients with uncontrolled metabolic diseases;
- •patients with AMI in the last 6 months;
- •patients on hemodialysis treatment;
- •patients who underwent chemotherapy and/or radiotherapy in the last year;
- •patients on immunosuppressive therapy;
- •patients on anti-resorptive and anti-angiogenic therapy;
- •patients with concomitant acute diseases at the time of the study;
- •patients with proven psychiatric diseases;
- •pregnancy.
- •There are local contraindications:
- •insufficient volume of bone after the extraction to carry out RP;
- •acute inflammatory disease or tumor process in the area;
- •Lack of informed consent.
- •Lack of patient motivation for the treatment.
结局指标
主要结局
Vertical post-extraction resorption of the socket walls
时间窗: 3 months
Each socket wall is measured using CBCT right after the extraction and after 3 months to assess the vertical resorption.
次要结局
未报告次要终点
研究者
Ralitsa Yotsova
Dr.
Medical University of Varna