A clinical study comparing effectiveness of intranasal versus intravenous dexmedetomidine for attenuation of hemodynamic responses of laryngoscopy and endotracheal intubation n patients undergoing general anaesthesia.
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Heart Rate
研究概览
简要总结
There are many literature regarding intravenous dexmedetomidine in attenuating the response to laryngoscopy and intubation but there is a lack of enough literature regarding intranasal use of dexmedetomidine for attenuation of response to laryngoscopy and intubation. Intranasal route is helpful preferred as it avoids needle anxiety and semi invasive.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA (American Society of Anesthesiologists) grade 1 and 2.
排除标准
- •Patient refused to participate Patient with known allergy and hypersensitivity to study drug.
结局指标
主要结局
Heart Rate
时间窗: Baseline,10 minute, 20 minute, 30 minute, 40 minute, At Induction, At laryngoscope and Intubation, 1minute, 2 minute, 3minute, 4 minute, 7 minute, 10 minute.
Systolic Blood Pressure
时间窗: Baseline,10 minute, 20 minute, 30 minute, 40 minute, At Induction, At laryngoscope and Intubation, 1minute, 2 minute, 3minute, 4 minute, 7 minute, 10 minute.
Diastolic Blood Pressure
时间窗: Baseline,10 minute, 20 minute, 30 minute, 40 minute, At Induction, At laryngoscope and Intubation, 1minute, 2 minute, 3minute, 4 minute, 7 minute, 10 minute.
MAP (Mean arterial pressure)
时间窗: Baseline,10 minute, 20 minute, 30 minute, 40 minute, At Induction, At laryngoscope and Intubation, 1minute, 2 minute, 3minute, 4 minute, 7 minute, 10 minute.
次要结局
- Post-operative sedation(Ramsay sedation score)(Baseline, At Intubation, 1 Hour, 2 Hour, 4 Hour, 6 Hour.)
研究者
PAVANKUMAR S HANDRAL
Subharti Medical College