Clinical Study to Determine the Optimal Operation Parameters During CO2 Removal With the Abylcap® System.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 4
- 试验地点
- 2
- 主要终点
- calculation of CO2 extraction in blood samples during mechanical ventilation
研究概览
简要总结
This prospective study includes 5 patients with ARDS (Acute Respiratory Distress Syndrome) treated by mechanical ventilation. In case of respiratory acidosis, extracorporeal CO2 (carbon dioxide)removal might be necessary. We hereby work with the Abylcap system with the oxygenator Lilliput2 as CO2 remover (Bellco, Italy).
The patients (M/V) are older than 18, not pregnant, have a BMI<30, and no contraindication for anticoagulation therapy.
Under standard conditions patients are treated with a blood flow of QB=300mL/min and a gas flow (100% 02) of QG=7L/min. Blood sampling is performed from the arterial bloodline in the patients at 0, 1h, 3h, 24h, 48h, 72h, 96h, and 120h.
A parameter study is also performed to optimise CO2 removal. Herewith, blood samples (1mL) are taken from the inlet and outlet line of the Lilliput2 at the previously mentioned time points and for different flow setting: Blood flow (QB) 200-300-400mL/min and gas flow (QG) 1.5, 3, 6, 7, 8L/min
Blood samples are analysed for the different blood gases from which the extraction in the CO2 remover can be calculated for each setting of QB (blood flow) and QG (gas flow).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with ARDS and respiratory acidosis on the intensive care unit
- •Treated with the Abylcap system (Bellco, Italy)
- •Not pregnant
排除标准
- 未提供
结局指标
主要结局
calculation of CO2 extraction in blood samples during mechanical ventilation
时间窗: during mechanical ventilation with CO2 removal (max up to 120h)
Extraction is calculated from the relative difference in blood gases at the inlet and outlet of the CO2 remover.
次要结局
- Based on the extraction rates, the optimum parameter settings are derived(During mechanical ventilation with CO2 removal (max up to 120h))