Beta-Cell Function in Young Turner Syndrome Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Beta-Cell Function measured as Disposition Index
研究概览
简要总结
Turner Syndrome is a common genetic disorder. Seventy percent of adults with Turner Syndrome have abnormalities in glucose metabolism which can lead to diabetes. The current screening guidelines for diabetes in Turner Syndrome are not specific and involve a fasting blood sugar once a year. The objective of this study is to determine if there are abnormalities in glucose metabolism and pancreatic function in young girls with Turner Syndrome. The study hypothesis is that pancreatic dysfunction (specifically of the beta cells that make insulin) is more prevalent in girls with Turner Syndrome compared to healthy controls.
详细描述
The study will be conducted at Children's Hospital Medical Center, Cincinnati. The study will require 1 visit to the hospital where the subject will have an oral glucose tolerance test and a physical exam
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 6 Years 至 22 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Turner Syndrome confirmed by chromosomal testing
- •On standard therapy (growth hormone and or estrogen)
排除标准
- •Type 1 or Type 2 diabetes
- •Polycystic Ovarian Syndrome
- •Pregnancy
- •On any medications that alter blood sugar
- •Healthy Female Controls:
- •Inclusion Criteria:
- •Exclusion Criteria:
- •Type 1 or Type 2 diabetes
- •Polycystic Ovarian Syndrome
- •Pregnancy
- •On any medications that alter blood sugar
结局指标
主要结局
Beta-Cell Function measured as Disposition Index
时间窗: 1 day at screening
Disposition index will be calculated based on the results of the oral glucose tolerance test using minimal modeling (computer program)
次要结局
未报告次要终点