NCT01137253已完成1 期
The Autonomic Nervous System, Nitric Oxide and TPA Interactions
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- Endothelial Function
研究概览
简要总结
The investigators are interested in the role of the autonomic nervous system in the regulation of endothelial function among obese hypertensive subjects. In particular, the investigators will study how endothelial function (response to intra-arterial acetylcholine) changes during autonomic withdrawal.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Trimethaphan
Experimental
Response to intrabrachial vasodilators during autonomic withdrawal
干预措施: Trimethaphan (Drug)
Placebo
Placebo Comparator
Response to intrabrachial vasodilators during saline intravenous (IV) infusion
干预措施: Placebo (Drug)
结局指标
主要结局
Endothelial Function
时间窗: 2 hours
The dose response curve to intrabrachial vasodilators will be determined using the peak forearm blood flow during the last 5 minutes of each drug infusion
次要结局
未报告次要终点
研究者
Alfredo Gamboa
Research Assistant Professor
Vanderbilt University
研究点 (1)
Loading locations...
相似试验
已完成
不适用
The Analysis of Autonomic Nervous System, Oxidative Stress, Metabolites according to Exercise Intensity of Aerobic Exercise in Sleep Deficiency ConditioKCT0006684Korea University32
尚未招募
Unknown
Involvement of autonomic nervous system regulation in modulation of joint position sense by an above-knee compression garmentHealthyJPRN-UMIN000048832Tohoku University Graduate School of Biomedical Engineering40
已完成
不适用
The Autonomic Nervous System and the Metabolic SyndromeObesityNCT00580957Vanderbilt University56
招募中
不适用
Hypercapnia in Orthostatic HypotensionNeurogenic Orthostatic HypotensionOrthostatic HypotensionNCT05295810University of Calgary80
已完成
早期 1 期
Autonomic Neuropathy, GI Motility, and Inflammation in HIVHIV DiseaseNCT02850276Icahn School of Medicine at Mount Sinai76