Influence of Short-Term Conventional Cuff-Assisted Training on Mitochondrial Capacity: A Non-Invasive Investigation
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 51
- 主要终点
- Determination of changes in the mitochondrial capacity of skeletal muscle (of the thigh muscle, vastus lateralis; measured non-invasively)
研究概览
简要总结
This study investigates low-load, cuff-assisted training to improve mitochondrial capacity. The intervention is carried out using automated pressure cuffs, applying an individualized pressure of 70% of the limb occlusion pressure. This approach reflects the current scientific consensus for safe and effective use in clinical populations.
Within a rehabilitation setting, two training modalities are compared: intermittent strength training and alternating continuous endurance training. Muscle oxygen saturation is measured non-invasively using near-infrared spectroscopy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Medically confirmed generalized deconditioning with reduced muscle strength
- •Medical certification of suitability for functional lower-extremity strength training
- •Written informed consent after an adequate reflection period
排除标准
- •Unstable arrhythmias, myocardial ischemia, symptomatic blood pressure drops or hypertension (>160/100 mmHg despite medication)
- •History of thrombosis or acute swelling/skin discoloration of the legs
- •Dizziness, confusion, cyanosis, or unexplained fatigue
- •Participant's wish to withdraw or not participate
结局指标
主要结局
Determination of changes in the mitochondrial capacity of skeletal muscle (of the thigh muscle, vastus lateralis; measured non-invasively)
时间窗: From enrollment to the end of treatment at 6 weeks.
次要结局
- Minimum and maximum oxygen saturation (SmO₂) during application of pressure cuffs (measured via NIRS)(From enrollment to the end of treatment at 6 weeks.)
- Changes in total hemoglobin (tHb) as a measure of local blood volume (measured via NIRS)(From enrollment to the end of treatment at 6 weeks.)
- Assessment of subjective functional mobility using the "Lower Extremity Functional Scale" (LEFS) questionnaire(From enrollment to the end of treatment at 6 weeks.)
研究者
Hannes Bossung
Master of Science
Spital Thurgau AG