Pathophysiology of Inflammation After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
试验速览
- 阶段
- 不适用
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- C reactive protein (CRP) mg/l, receiver operating characteristic (ROC)
研究概览
简要总结
The purpose of this study is to assess the dynamics of inflammatory parameters in presence or absence of infectious complications after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.
详细描述
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy is the treatment of choice in patients with primary or secondary peritoneal surface malignancies. However the survival benefit is achieved at the cost of increased morbidity and mortality due to an extensive surgery and intraoperative chemo-therapy. Among complications infectious complications are the most common. The early diagnosis of a potential fatal infection is therefore crucial to ensure a good outcome in patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Consecutive adult patients (more than 18 years) subjected to CRS and HIPEC due to peritoneal malignancy.
- •Written informed consent by the participant after information about the research project
排除标准
- •No primary or secondary peritoneal surface malignancy
- •No CRS and HIPEC
- •Pregnancy
- •Younger than 18 years
结局指标
主要结局
C reactive protein (CRP) mg/l, receiver operating characteristic (ROC)
时间窗: 30 days
次要结局
未报告次要终点