Development of a Reliable Neurophysiological Pain Assessment Tool: Alpha as a Predictive Biomarker
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- Peak Alpha Frequency (Hz)
研究概览
简要总结
The investigators will use non-invasive recordings of brain activity to measure pain as a proxy to self-report. Participants will undergo testing for about 3 hours on two separate days. The testing will involve experiencing painful heat.
详细描述
Neurophysiological investigations of pain have suggested that electroencephalograph (EEG) measures of peak alpha frequency might provide a means of pain assessment. In healthy subjects, increased peak alpha frequency is strongly correlated with pain self-reports after exposure to acute noxious heat. Conversely, chronic pain patients compared to healthy control display decreased peak alpha frequencies higher in alpha power. Measures of peak alpha frequency also show a negative relationship with disease duration, suggesting that peak alpha frequency may not only index ongoing pain but also disease progression. The overall aim is to determine the predictive accuracy, reliability, and specificity of EEG alpha activity in acute pain and a model of neuropathic pain in healthy subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 44 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Able to speak, read, and write English
- •Between 21 and 44 years of age
- •Able to understand and willing to comply with all study procedures and is available for the duration of the study
- •Free of an acute or chronic pain condition
- •Not history of psychiatric or neurologic condition
排除标准
- •Unable to undergo EEG, assessed on an individual basis
- •History of unstable major psychiatric disorder (self-report)
- •History of chronic pain (self-report)
- •More than 14 alcoholic drinks per week on average (self-report)
- •Active [within 6 months] substance or alcohol abuse (self-report and urine toxicology)
- •Use of opioids (self-report and urine toxicology)
- •History of major depressive disorder (self-report)
- •Pregnant or Lactating (women only), based on (self-report and urine test)
- •Anything that, in the opinion of the investigator, would place the subject at increased risk or preclude the subject's full compliance with or completion of the study
- •Uncontrolled (systolic blood pressure > 175 mmHg or diastolic blood pressure >105 mmHg) or unstable hypertension
结局指标
主要结局
Peak Alpha Frequency (Hz)
时间窗: pain-free and pain states at the baseline visit
The highest power of EEG-based alpha activity in the 8-12Hz frequency range, calculated using the center of gravity method.
次要结局
- Alpha Wave Activity Reliability(alpha activity at pain-free and pain states, assessed at a second visit following the first visit by at least 3 week)
研究者
David Seminowicz
Associate Professor, Department of Neural and Pain Sciences
University of Maryland, Baltimore