NCT05360576已完成2 期
An Open-label, Randomized, 2-Period, Crossover Study to Assess the Comparative Pharmacokinetics of LSP-5415 and NuvaRing® in Healthy Adult Females
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Pharmacokinetics (Cmax)
研究概览
简要总结
An Open-label, Randomized, 2-Period, Crossover Study to Assess the Comparative Pharmacokinetics of LSP-5415 and NuvaRing® in Healthy Adult Females
详细描述
This is an open-label, randomized-sequence, two-period, single-center, crossover, pharmacokinetic study in 40 healthy adult female subjects (18- 40 years). All subjects will receive LSP-5415 (28 days) and NuvaRing (28 days) under fasted conditions. There will be a 28-day washout period after ring removal in Treatment Period 1 and ring insertion in Treatment Period 2.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Must be able, and willing, to sign Informed Consent Form prior to study participation in accordance with legal requirements.
- •Females (18 to 40 years of age, inclusive) without uncontrolled concomitant disease at Baseline Visit.
- •Have a regular menstrual cycle that is 24-32 days in duration.
- •Body Mass Index (BMI) of 18 kg/m2 to 30 kg/m
- •Will not be at risk for pregnancy, subjects must agree to consistently use reliable non-hormonal contraceptive methods (spermicide-coated condoms, male partner's sterilization via vasectomy, or sexual abstinence), or be in a same-sex relationship from screening through study completion, or be surgically sterilized by bilateral tubal ligation. -
- •Subjects must be in good physical and mental health as determined by vital signs, medical history.
- •Subjects must have a Blood Pressure reading in a sitting position, between 90-140 mmHg (systolic) and 50-90 mmHg (diastolic) and pulse rate between 50 and 100 bpm.
- •Be at least 3 months after a delivery or abortion.
- •Willing to abstain from vaginal products e.g., tampons, intravaginal medications etc. during the ring wear period for the study duration except water based vaginal lubricants/spermicides.
排除标准
- •Pregnancy, a positive serum ß-hCG pregnancy test at screening or lactation.
- •Use of tobacco- or nicotine-containing products (e.g., cigarette, pipe, cigar, chewing, vaping, nicotine patch, or nicotine gum) within 6 months prior to check-in on Day -
- •Have a history of cervical carcinoma or other carcinomas of the vagina or vulva.
- •Have a history of breast cancer or any hormonally sensitive cancer.
- •Subjects with abnormal pap smears that require colposcopic evaluations as defined by the fourth American Society of Colposcopy and Cervical Pathology (ASCCP) sponsored guidelines for management of cervical cancer abnormalities during the next 6 months are excluded until they have undergone colposcopic evaluation which has determined that a cervical procedure is not necessary during the 6 months following the colposcopy.
- •History of thrombophlebitis, venous or arterial thromboembolic diseases (thrombosis, pulmonary embolism, stroke or myocardial infarction).
- •Any known severe neurological, gastrointestinal, hepatic or other disease that might interfere with the intake of an investigational drug or any study condition.
- •Clinically relevant findings from serum biochemistry and hematology and HBsAg and C Virus/HlV serology as evaluated by the investigator.
- •Clinically relevant/significant electrocardiogram (ECG) findings.
- •Additional contraindications related to the use of ethinyl estradiol (EE), or hormonal contraceptives including women with a high risk of arterial or venous thrombotic diseases. Examples include women who are known to:
- •Have cerebrovascular disease
- •Have coronary artery disease
- •Have thrombogenic valvular or thrombogenic rhythm diseases of the heart (for example, subacute bacterial endocarditis with valvular disease, or atrial fibrillation)
- •Have inherited or acquired hypercoagulopathies
- •Have uncontrolled hypertension
- •Have diabetes mellitus with vascular disease
- •Have headaches with focal neurological symptoms or migraine headaches with aura
- •History of migraine with focal neurological symptoms.
- •Known hereditary or acquired predisposition for venous and/or arterial thromboembolism (e.g., activated protein C [APC] resistance, anti-cardiolipin antibodies).
- •Less than 2 weeks remobilization after major surgery or prolonged immobilization
- •Alcohol, drug, or medicine abuse, or suspicion thereof.
- •Known allergy to any ingredient of the investigational drug.
- •Use of long-acting injectable or implant hormonal therapy. A washout period of 10 months and two regular cycles is required for long-acting injectable contraceptive therapy or implant hormonal therapy (e.g., depo-medroxyprogesterone) prior to the start of screening.
- •Use of hormonal or non-hormonal IUDs within 30 days prior to the start of screening.
- •Participation in another clinical trial at same time or within the preceding three months
- •Not fulfilling study specific requirements at screening.
- •Subjects desire to become pregnant during the Study.
- •Undiagnosed vaginal discharge/bleeding, vaginal lesions/ abnormalities or undiagnosed abnormal uterine bleeding. Subjects suspected of having a vaginal infection (e.g., chlamydia, gonococcus, yeast, trichomoniasis, or bacterial vaginosis, etc.) may be enrolled after treatment and subsequent negative test results; partner treatment is also recommended (as per treatment guidelines).
- •Regular intake or use of the following medication:
- •any drugs that might interfere with the investigational drug.
- •any hormonal preparation 30 days prior to the start of screening (except for treatment for thyroid disorders under control).
- •any drugs known to induce liver enzymes (e.g., rifampicin, dexamethasone, barbiturates, anticonvulsants, St. John's Wort).
- •any drugs known to inhibit CYP 3A4 (e.g. ketoconazole, verapamil, cimetidine, macrolides).
- •any broad-spectrum antibiotics.
- •use of Hepatitis C drug combinations containing ombitasvir/paritaprevir/ritonavir, with or without dasabuvir, due to potential for ALT evevations
研究组 & 干预措施
NuvaRing® (etonogestrel/ethinyl estradiol 11.7/2.7 mg)
Active Comparator
Reference Product
干预措施: NuvaRing Vaginal Ring (Drug)
LSP-5415 (etonogestrel/ethinyl estradiol vaginal ring)
Experimental
Test Product
干预措施: LSP-5415 (etonogestrel/ethinyl estradiol vaginal ring) (Drug)
LSP-5415 (etonogestrel/ethinyl estradiol vaginal ring)
Experimental
Test Product
干预措施: NuvaRing Vaginal Ring (Drug)
NuvaRing® (etonogestrel/ethinyl estradiol 11.7/2.7 mg)
Active Comparator
Reference Product
干预措施: LSP-5415 (etonogestrel/ethinyl estradiol vaginal ring) (Drug)
结局指标
主要结局
Pharmacokinetics (Cmax)
时间窗: 28 Days
To assess the pharmacokinetics (PK) (Cmax) of etonogestrel (ENG) and ethinyl estradiol (EE) following LSP-5415 (28 days) and NuvaRing (28 days) administration.
Pharmacokinetics (Tmax)
时间窗: 28 Days
To assess the pharmacokinetics (PK) (Tmax) of etonogestrel (ENG) and ethinyl estradiol (EE) following LSP-5415 (28 days) and NuvaRing (28 days) administration.
Pharmacokinetics (AUC)
时间窗: 28 Days
To assess the pharmacokinetics (PK) (AUC) of etonogestrel (ENG) and ethinyl estradiol (EE) following LSP-5415 (28 days) and NuvaRing (28 days) administration.
Safety (Number of study subjects with treatment-emergent adverse events)
时间窗: 3 months
To assess the safety of LSP-5415 and NuvaRing in healthy adult female subjects.
次要结局
未报告次要终点
研究者
研究点 (1)
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