COVID-19 and Childhood Cancer - Diagnostic Delay, Survival, and COVID-19 Susceptibility
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 100,000
- 试验地点
- 1
- 主要终点
- Childhood cancer survival
研究概览
简要总结
The investigators will first examine the impact of the COVID-19 pandemic on childhood cancer patients in Sweden and Denmark, both regarding susceptibility to severe COVID-19 among long-term childhood cancer survivors, and, for those diagnosed with childhood cancer during the pandemic, whether the path through primary care to cancer diagnosis as well as short-term survival has changed. Second, the investigators will study childhood cancer incidence before, during and after the pandemic with the particular aim to test the hypothesis regarding an infectious disease etiology for acute lymphoblastic leukemia.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 0 Years 至 19 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •No exclusion criteria
结局指标
主要结局
Childhood cancer survival
时间窗: After three and twelve months after the cancer diagnosis and three years after cancer diagnosis
Overall survival after a childhood cancer diagnosis
Severe COVID-19
时间窗: Up to 3 years
Defined as: * death with COVID-19 listed as a cause of death * hospitalization, or admission to intensive care unit, because of COVID-19 (main diagnosis) or respiratory problems (main diagnosis) AND COVID-19 as secondary diagnosis
Number of contacts before childhood cancer diagnosis
时间窗: One year before cancer diagnosis
Number of healthcare contacts (including primary care) the year before the cancer diagnosis
Childhood cancer incidence
时间窗: From 2015
Age standardized incidence rates for childhood cancer and cancer subtypes (particularly acute lymphoblastic leukemia) in Sweden and Denmark during and after the pandemic and compare it to the 5 years preceding the pandemic
次要结局
未报告次要终点
研究者
Giorgio Tettamanti
Senior research specialist, Docent
Karolinska Institutet