Tailored lymphadenectomy using Sentinel node Navigation surgery in submucosal esophageal Adenocarcinoma Patients: SNAP-III study

niversity Medical Center Utrecht0 个研究点目标入组 10 人开始时间: 待定最近更新: 2024年6月11日

适应症

试验速览

暂无简介。

•1)High-risk submucosal EAC on histology (diagnosed in ER specimen) confirmed by an expert gastrointestinal pathologist, defined as:
•a) Infiltration of EAC into the deep submucosa (>500 µm), and/or;
•b) Poor differentiation (G3) or undifferentiated (G4) EAC, and/or;
•c) Presence of lymphovascular invasion
•2)Tumor-free deep vertical resection margins in the ER specimen
•3)Clinically staged as T1N0M0
•4)Fit for endoscopy and surgery per institution’s standards
•5)Older than 18 years of age at time of informed consent
•6)Willing and able to comply with follow-up requirements
•7)Written informed consent

•1)History of esophageal squamous cell carcinoma
•2)Clinically staged as N+
•3)Prior neoadjuvant chemoradiation therapy
•4)Prior esophageal surgery interfering with the procedure
•5)Other primary tumor with a life-expectancy less than 3 years
•6)Known allergy for the radioactive tracer (technetium) or dye (indocyanine green)
•7)Severe medical comorbidities precluding endoscopy and/or surgery
•8)Pregnant or planning to become pregnant during period of study
•9)Refusing or unable to provide written informed consent
•10)Participation in another study within the 30 days preceding or during the present study, interfering with participation in the current study

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