NCT02985580已完成不适用
Effects of Blueberry Juice Consumption on Brain Activation and Perfusion in Healthy Older People
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 主要终点
- Brain perfusion
研究概览
简要总结
Blueberries are rich in flavonoids that possess antioxidant and anti-inflammatory properties, which in rodent models are neuro-protective. The risk of developing dementia is reduced in people habitually consuming high flavonoid intakes, but data from human intervention studies is sparse. We therefore investigated whether 12 weeks of blueberry concentrate supplementation improved cognitive function in healthy elderly via increased brain activation and perfusion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •aged 60-80y
- •Addenbrooke's Cognitive Examination III questionnaire > 88
- •Consuming 5 or less portions of fruit per day
排除标准
- •Addenbrooke's Cognitive Examination III questionnaire < 88 Contraindications for MRI Consuming more than 5 portions of fruit per day
研究组 & 干预措施
Placebo
Placebo Comparator
Placebo concentrate consumed daily for 12 weeks.
干预措施: Placebo (Dietary Supplement)
Blueberry
Active Comparator
Blueberry concentrate consumed daily for 12 weeks.
干预措施: Blueberry (Dietary Supplement)
结局指标
主要结局
Brain perfusion
时间窗: Change from baseline to 12 weeks dietary supplementation
MRI - arterial spin labelling
次要结局
- Brain activation(Change from baseline to 12 weeks dietary supplementation)
- Cognitive function tests(Change from baseline to 12 weeks dietary supplementation)
- Blood biomarkers of inflammation(Change from baseline to 12 weeks dietary supplementation)
- Blood biomarkers of oxidative stress(Change from baseline to 12 weeks dietary supplementation)
- Blood biomarkers of neurogenesis(Change from baseline to 12 weeks dietary supplementation)
研究者
相似试验
尚未招募
不适用
The Acute Effects of Blueberries on Cognition and Mood in the PostpartumMoodParentsHealthyNCT06402916University of Reading60
已完成
不适用
Blueberry Intervention Study for Brain AgingBrain AgingNCT05024916University of Kansas Medical Center63
已完成
1 期
Effect of Elderberry Juice on Cognition and Inflammation in Patients With Mild Cognitive ImpairmentMild Cognitive ImpairmentNCT02414607University of Missouri-Columbia24
Unknown
不适用
Effects of Blueberries on Symptoms and Underlying Mechanisms of Functional Gastrointestinal DisordersFunctional Gastrointestinal DisordersNCT04824976Brain-Gut Research Group55
已完成
不适用
Blueberry Enhances Activity and Cognition Through Increased Vascular EfficiencyArterial StiffnessBlood PressureSedentary LifestyleOverweight and ObesityNCT04049162Duke University84