Examining the Role of Female Endogenous Sex Hormones in Eccentric Exercise
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Inflammatory Response
- 发起方
- University of Southern California
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Preparedness to perform
- 状态
- 招募中
- 最后更新
- 上个月
概览
简要总结
The fluctuating concentrations of female sex hormones, namely estrogen and progesterone may have an effect on the ability of the tissue to withstand challenging exercise conditions, such as eccentric exercise. These sex hormones have also been purported to influence the perceived difficulty of exercise. This study aims to uncover how the different estrogen and progesterone concentrations present throughout the menstrual cycle effect perceived readiness to perform, perceptions of difficulty, and different recovery metrics.
详细描述
Although nearly half of the population is female, less than 10% of research resources are allocated to understanding how their dynamic physiology impacts athletic readiness, performance, and recovery. The fluctuating concentrations of female sex hormones, namely estrogen and progesterone may have an effect on the ability of the tissue to withstand challenging exercise conditions, such as eccentric exercise. This study aims to uncover how the different estrogen and progesterone concentrations present throughout the menstrual cycle effect perceived readiness to perform, perceptions of difficulty, and the inflammatory environment and quantification of muscle damage.
研究者
Todd Schroeder
Professor
University of Southern California
入排标准
入选标准
- •18-35 years of age
- •BMI of 18.5-29.9 as a BMI below or above these cut points results in highly varied menstrual cycle lengths \[15\]
- •Not taking contraception or other types of medication that could influence reproductive status
- •Regular menstruation
- •Non-pregnant
- •Medically free from chronic diseases
- •Novel to downhill running
- •Weight greater than or equal to 110 lbs
- •Not taking exogenous hormones
- •Not suffering from known gynecological disease (i.e., PCOS, endometriosis, etc.) that may influence menstrual cycle regularity
排除标准
- •Amenorrhea or oligomenorrhea
- •Perimenopausal or menopausal
- •Recreational or professional trail or downhill runner
- •On a form of contraception
- •Cardiac disability
- •Pacemaker
- •Arterial disease
- •Uncontrolled hemorrhage
- •Blood clots
- •Pregnant or trying to become pregnant
结局指标
主要结局
Preparedness to perform
时间窗: Pre exercise
Perceived readiness will be measured on an 11 point numeric rating scale (NRS) with 0 being not ready at all, and 10 being most prepared
Rating of difficulty
时间窗: 30 minutes
Perceived difficulty will be measured on a 11 point numeric rating scale called the OMNI res throughout the duration of exercise.
Inflammatory markers
时间窗: Change over time (pre/post, 24 hour, 48 hour)
Inflammatory markers (IL-6, IL-8, TNF-alpha, and IL-10) will be measured in blood serum to understand how the concentration of estrogen changes the inflammatory response to damaging exercise.
Counter movement jump height
时间窗: Change over time (pre/post, 24 hour, 48 hour)
A countermovement jump (CMJ) will be performed on VALD ForceDecks to determine muscle function overtime.
Active Delayed Onset Muscle Soreness (DOMS)
时间窗: Change over time (pre/post, 24 hour, 48 hour)
DOMS will be assessed as participants complete a wall sit to assess their perception of muscle soreness over time.
Passive Delayed Onset Muscle Soreness (DOMS)
时间窗: Change over time (pre/post, 24 hour, 48 hour)
DOMS will be assessed as participants are stationary to assess their perception of muscle damage over time.