ACTRN12615000403538终止4 期
Randomized Control Trial of Meropenem versus Piperacillin-Tazobactam on mortality and clinial response in patients with bloodstream infections due to ceftriaxone non-susceptible Escherichia Coli and Klebsiella species.
Australasian Society of Infectious Diseases Clinical Research Network0 个研究点目标入组 454 人开始时间: 2015年4月30日最近更新:
试验速览
- 阶段
- 4 期
- 状态
- 终止
- 发起方
- 入组人数
- 454
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •1. Bloodstream infection with Escherichia coli or Klebsiella spp., as defined by at least one positive blood culture from a peripheral blood draw.
- •2. Bacteria confirmed as ceftriaxone non-susceptible, Piperacillin-Tazobactam susceptible and Meropenem susceptible by use of EUCAST definitions (www.eucast.org).
- •3. No more than 72 hours since the first positive blood culture was collected for this infection.
- •4. Patient or their ethics committee approved proxy able to give written informed consent.
排除标准
- •1. Patient not expected to survive more than 4 days.
- •2. Patient allergic to a penicillin or a carbapenem.
- •3. Patient with significant polymicrobial bacteraemia (that is, a Gram positive skin containment in one set of blood cultures is not regarded as significant polymicrobial bacteraemia).
- •4. Treatment is not with the intent to cure the infection (that is, palliative care is an exclusion).
研究者
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