Exercise Capacity and Single Photon Emission Computed Tomography in Liver Transplantation Candidates Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 403
- 主要终点
- Cardiovascular mortality
研究概览
简要总结
The optimal screening strategy for assessment of coronary artery disease in patients with end-stage liver disease (ESLD) is unclear. Although consensus based guidelines support noninvasive stress testing prior to orthotopic liver transplantation (OLT), no prospective studies are available to inform the clinician on perioperative risk stratification. This observational cohort study was designed to determine the prognostic utility of single photon emission computed tomography (SPECT) imaging in OLT candidates.
详细描述
Controversy over whether SPECT imaging offers clinical utility in ESLD has been fuelled by conflicting reports on its accuracy to diagnose CAD in this setting. Moreover, there are no studies examining whether SPECT imaging provides any incremental prognostic value beyond functional testing in this high-risk cohort. We sought to determine the relative importance of CV risk factors, functional capacity and SPECT perfusion results as independent predictors of cardiovascular mortality in OLT candidates.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Liver transplantation candidates with one or more of the following:
- •inability to perform >4 METs by history
- •insulin-treated diabetes mellitus
- •serum creatinine >152μmol/l
- •history of MI, PCI or CABG
- •stable angina
- •cerebrovascular disease
- •peripheral vascular disease
排除标准
- •Age < 18 years
- •Pregnancy
- •Contraindication to liver transplantation
结局指标
主要结局
Cardiovascular mortality
时间窗: 10 years
次要结局
- Major adverse cardiovascular event(10 years)
- All-cause mortality(10 years)
研究者
William E Moody
Consultant Cardiologist with a Specialist Interest in Cardiac Imaging
University Hospital Birmingham NHS Foundation Trust