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临床试验/NCT02427152
NCT02427152Unknown不适用

Pre-meal Planning and Expected Satiety

University Hospital Tuebingen1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2015年3月最近更新:
适应症

试验速览

阶段
不适用
入组人数
60
试验地点
1
主要终点
Differential brain functions in reward, decision making and inhibitory control networks (brain functions will be measured by blood oxygen level dependent effects)

研究概览

简要总结

Obesity is considered to be caused by an imbalance between energy expenditure and energy intake. A major determinant of our daily energy intake is the size of the meals that we consume. It has been suggested that decisions about portion sizes are often made in advance, before a meal begins. This pre-meal planning is considered to especially depend on the estimated 'expected satiety' and 'expected satiation' of different foods. Further, also factors like weight concern and palatability of the food might have their influence on meal size selection. In general, it is not clear how these factors are integrated during pre-meal planning and which brain networks are involved in these decisions/this process. Thus, the investigators plan to study pre-meal planning in healthy, normal-weight and overweight/obese individuals with functional magnetic resonance imaging under different cognitive instructions including pleasure, expected satiety and self-control in terms of health consequences. The investigators will explore the neural networks involved in pre-meal planning and expect them to be modulated by the before mentioned factors. Further, the investigators plan to explore gender differences and expect that female subjects will select smaller portion sizes especially in the self-control condition as they are often more concerned about their weight/health. Finally, the investigators will explore differences between lean and overweight subjects to elucidate factors that might lead to increased meal sizes in overweight subjects.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Cross Sectional

入排标准

年龄范围
18 Years 至 35 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • body mass index: 18-25 kg/m²; 25-35 kg/m²,
  • right-handed,
  • age: 18-35 years.

排除标准

  • functional magnetic resonance imaging contraindications,
  • claustrophobia,
  • self-reported eating disorders,
  • vegan or vegetarian diet, food allergies,
  • intake of antidepressants,
  • metabolic disorders.

结局指标

主要结局

Differential brain functions in reward, decision making and inhibitory control networks (brain functions will be measured by blood oxygen level dependent effects)

时间窗: day 0

brain functions will be measured by blood oxygen level dependent effects

次要结局

  • Differential behavioral measures of portion size selection(day 0)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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