Correlation Between Optical Coherence Tomography Angiography and Photopic Negative Response in Patients With Primary Open Angle Glaucoma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 76
- 试验地点
- 1
- 主要终点
- Correlation between vascular, structural and functional changes of the peripapillary retinal nerve fiber and macular ganglion cell complex in patients with open angle glaucoma.
研究概览
简要总结
Open angle glaucoma (OAG) is considered a common cause of irreversible vision loss worldwide. It is an optic neuropathy associated with progressive loss and degeneration of the retinal ganglion cell layer (RGC) and its axons (retinal nerve fiber layer; RNFL), which lead to neuroretinal rim excavation and corresponding visual field defects.
详细描述
Open angle glaucoma (OAG) is considered a common cause of irreversible vision loss worldwide. It is an optic neuropathy associated with progressive loss and degeneration of the retinal ganglion cell layer (RGC) and its axons (retinal nerve fiber layer; RNFL), which lead to neuroretinal rim excavation and corresponding visual field defects.
OCT Angiography (OCTA) is a promising tool for diagnosing and monitoring glaucomatous patients. It can evaluate glaucomatous damage and assess the ganglion cells' health by measuring blood flow within the optic nerve and the retina Correlation between vascular , structural and functional changes of the peripapillary retinal nerve fiber (RNFL) and macular/ganglion cell complex (GCC) can lead to early detection of glaucomatous changes.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 35 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age of 30 years or older for both control and glaucoma groups.
- •Spherical equivalent (SE) between -2 and +2 D.
- •No history of previous eye surgery, trauma, or systemic diseases.
排除标准
- •Spherical equivalent greater than +/- 2.00 diopters (D).
- •Media opacity as (cataract or corneal scar).
- •Any history of ocular surgeries or trauma.
- •Optic nerve anomaly or other retinal diseases.
- •Unreliable visual field tests (33% fixation losses, false positive, and false- negative results).
结局指标
主要结局
Correlation between vascular, structural and functional changes of the peripapillary retinal nerve fiber and macular ganglion cell complex in patients with open angle glaucoma.
时间窗: Immediately after OCTA and electroretinogram diagnostic tests for each eye.
Correlation between RNFL thickness and GCC measured by OCT-A with implicit time and amplitude of Photopic Negative Response (PhNR) measured by electroretinogram.
次要结局
- Assess the validity of OCTA parameters and PhNR in early detection of glaucoma changes.(Immediately after OCTA and electroretinogram diagnostic tests for each eye.)
研究者
Ahmed Abdelshafy
Lecturer of Ophthalmology
Benha University