Effects of Muscle Cooling on Motor Unit Firing of the Quadriceps: A Pilot Feasibility Study
试验速览
- 阶段
- 不适用
- 状态
- 暂停
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Motor Unit (MU) Yield
研究概览
简要总结
The overall objective of this pilot study is to establish the feasibility and methodological validity of using high-density surface electromyography to characterize motor unit behavior of the quadriceps under thermoneutral and locally cooled conditions, and to generate preliminary data to inform the design of a larger, hypothesis-driven study.
详细描述
This randomized, cross-over pilot study will recruit 24 healthy young adults (12 men and 12 women) between the ages of 18 and 35 years. Participants will attend two in-person laboratory visits separated by a minimum of 48 hours. Visit 1 will include informed consent, eligibility confirmation, baseline assessments, and familiarization procedures. Visit 2 will include experimental testing under thermoneutral and cooled conditions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women between the ages of 18 and 35 years
- •Healthy adults, defined as absence of significant acute/chronic medical condition, injury, and/or illness that may compromise subject safety, limit the ability of the participant to complete the study, and/or compromise the objectives of the study as determined by the Principal Investigator.
排除标准
- •Current diagnosis or history of:
- •major metabolic disease (e.g., type I and type II diabetes),
- •neuromuscular disease (e.g., cervical spondylotic radiculomyelopathy, lumbar spondylosis, amyotrophic lateral sclerosis, Guillain-Barré syndrome, and acquired demyelinating polyneuropathies),
- •cardiovascular disease (e.g., stage II hypertension, heart failure, myocardial infarction/ischemia, peripheral vascular disease, Raynaud's phenomenon, or other conditions associated with impaired peripheral circulation),
- •significant myocardial or pericardial diseases (e.g. amyloidosis, constriction),
- •moderate or severe valvular disease,
- •pulmonary/respiratory disease (e.g., asthma, chronic bronchitis, emphysema, chronic obstructive pulmonary disease),
- •renal disease,
- •liver disease,
- •or anemia.
- •Current or recent musculoskeletal injury (e.g. fracture, sprain, dislocation) or any physical disability that precludes safe and adequate testing.
- •Pregnancy or breastfeeding.
- •Thigh circumference greater than 23 inches
- •Mid-thigh skinfold thickness greater 40 mm
研究组 & 干预措施
Sequence A
Those randomized to Group A (n=12, 50% men) will perform the thermoneutral condition first, followed by the cooled condition.
干预措施: Cryotherapy (Procedure)
Sequence B
Those randomized to Group B (n=12, 50% men) will perform the cooled condition first, followed by the thermoneutral condition.
干预措施: Cryotherapy (Procedure)
结局指标
主要结局
Motor Unit (MU) Yield
时间窗: Immediately after the intervention
Number of unique motor units successfully identified (decomposed) from quadriceps HDsEMG recordings during maximal voluntary contractions (MVCs) under thermoneutral and cooled conditions.
HDsEMG Decomposition Accuracy
时间窗: Immediately after the intervention
Quality/accuracy of motor unit decomposition from quadriceps HDsEMG recorded during MVCs under thermoneutral and cooled conditions, based on decomposition quality metrics generated by the Delsys Neuromap Precision Decomposition III algorithm.
Proportion of Analyzable MVC Trials
时间窗: Immediately after the intervention
Percentage of MVC trials that yield HDsEMG data suitable for motor unit decomposition and analysis under thermoneutral and cooled conditions (successful decomposition and acceptable signal quality).
次要结局
- Slope of MUAP-FR relationship(Immediately after the intervention)
- Y-intercept of MUAP-FR relationship(Immediately after the intervention)
研究者
Eliott Arroyo
Assistant Professor
Wake Forest University