Evaluation of Regional Ventilation Distribution Using Electrical Impedance Tomography During Weaning From Mechanical Ventilation
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Regional Ventilation distribution using Electrical Impedance Tomography
研究概览
简要总结
The goal of this physiological cross-over clinical trial is to evaluate the effect of different clinically used weaning trials on regional mechanical ventilation in a population of patients undergoing weaning from mechanical ventilation for acute respiratory failure.
The main question[s] it aims to answer are:
- to evaluate which weaning trial is associated to a better regional ventilation distribution
- to evaluate which weaning trial can be comparable to ventilation distribution after extubation
Participants will undergo 3 clinically used weaning trials in a random order (cross-over trial). Researchers will compare the different steps to see if regional ventilation distribution is different among the different trial .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Diagnostic
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 18 and < 70 years
- •Ready to be weaned from mechanical ventilation according to clinical criteria
排除标准
- •Age < 18 years or > 70 years
- •Presence of chest drains
- •Presence of pacemaker/impantable cardiac device;
- •diagnosis of Pneumothorax, or pneumomediastinum
- •Diagnois of neuromuscular diseases
- •Use of neuromuscular blockers in the 48 hours before screening;
- •Body mass index > 35 kg/m2
- •Refusal to participate of the patient/next of kin
结局指标
主要结局
Regional Ventilation distribution using Electrical Impedance Tomography
时间窗: 2 hours
The researchers will evaluate differences in ventilation distribution pattern among the different weaning trials using Electrical Impedance Tomography and focusing on: * Regional ventilation distribution * Regional inhomogeneity * Regional compliance distribution * Center of Ventilation * Silent Spaces
次要结局
- Differences in Regional Ventilation distribution using Electrical Impedance Tomography between weaning trials and post-extubation phase(48 hours)
研究者
Savino Spadaro
Principal investigator
Università degli Studi di Ferrara