An exploratory study for the development of novel individually optimized treatment using transcranial magnetic stimulation (TMS) for patients with mood disorders - The development of treatment for mood disorder by TMS

Okamoto Yasumasa0 个研究点目标入组 3 人开始时间: 2019年2月18日最近更新: 2023年10月17日

试验速览

Recruiting did not proceed and the research was discontinued.

•[ For patients/clients ]
•1) Aged 20-80 years old
•2) Being diagnosed as major depressive disorder or bipolar disorder (Type I, Type II) according to DSM-IV-TR or DSM-V
•3) Current diagnosis of major depressive episode
•4) Present treatment-resistance (scores with 14 points or above out of 17 items on the Hamilton Rating Scale for Depression even after >=4 weeks of treatment with sufficient amount of more than 2 kinds of anti-depressants) or low treatment-tolerance (insufficient administration due to side-effects while taking more than 2 kinds of anti-depressants)
•5) Satisfactory informed consent obtained from participant him/herself
•[ For healthy control ]
•1) Aged 20-80 years old
•2) No history of any psychiatric disorders
•3) Not having current serious medical illness
•4) Satisfactory informed consent obtained from the participant him/herself

•Rejection criteria common to both patients and healthy controls
•1) Decisionally impaired individuals who has diminished capacity to understand the aim of the research
•2) Physically impaired individuals who are not able to complete the experiments
•3) Subjects who are contraindicated for the use of TMS and MRI
•Having an implanted heart pace-maker
•Having implanted cerebral (arteries) clips
•Having implanted neural/nerve stimulators
•Having implanted pumps
•Having work experience in a metal industry or possibility of metal residues remaining in the body
•Having metal-tattoos (including tattooed eye-lining)
•Being pregnant, or having possibility of being pregnant
•4) Subjects who are contraindicated for the use of TMS
•Personal history of seizure disorder such as epileptic disorder
•5) Any individuals judged as inappropriate for the experiment by the principal investigator or a collaborating researcher
•6)Those participating in other intervention studies

发起方

Okamoto Yasumasa