跳至主要内容
临床试验/NCT05900297
NCT05900297尚未招募不适用

Antibiotic Regimen for Patients Seeking Dental Implants Procedures

Assiut University0 个研究点目标入组 100 人开始时间: 2023年9月15日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
100
主要终点
to limit the antimicrobial resistance by identifying the most suitable antibiotic regimen according to the intra-oral organisms

研究概览

简要总结

This study aims to:

  1. To identify the most common organisms causing dental implant failure.
  2. Set an appropriate antibiotic regimen according to the causative organism to limit the antimicrobial resistance by limit the use of antibiotics.

详细描述

Dental implant surgery is a common treatment for replacing missing teeth and has a high success rate. Implant failure is most likely the result of multiple factors as Age, sex, smoking, maxillary implant site, quantity and quality of bone, implant surface treatments and features are some of the statistically examined parameters linked to implant failure. The most frequent and avoidable cause of dental implant failure is infection. A retrospective analysis demonstrated fewer numbers of early implant failures among those that were placed under antibiotic treatments.

Early implant failure is commonly associated with certain strains of bacteria. The most common bacteria involved are streptococci, anaerobic Gram-positive cocci, and anaerobic Gram-negative rods.Porphyromonas gingivalis and Fusobacterium nucleatum frequently colonize the implant in early and late losses and could therefore be characteristic for implant loss in general.

Thus, the antibiotic to prevent delayed healing of wound should be bactericidal and of low toxicity. Systemic antibiotic prophylaxis has been used to reduce the risk of early implant failure and local infections around dental implants.Antibiotics are one of the most cost-effective, life-saving medicines and contribute to an extended lifespan. Access to antibiotics without a prescription is a driving factor for irrational antibiotic use due to a potential lack of access to proper diagnosis and diagnostic tools. This eventually leads to the development and spread of antibiotic resistance &it is one of the increasing public health challenges worldwide.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Cross Sectional

入排标准

年龄范围
18 Years 至 75 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Saliva samples from patients seeking dental implant procedures

排除标准

  • Immunodeficiency or immunosuppressing treatment
  • current antibiotic treatment
  • acute or chronic oral infection (including ongoing periodontal infection).

结局指标

主要结局

to limit the antimicrobial resistance by identifying the most suitable antibiotic regimen according to the intra-oral organisms

时间窗: september 2023-september 2024

according to the antibiogram at least 30 isolates from each species are needed to identify the most common organisms and set an appropriate antibiotic regimen for patients seeking dental implants.An antibiogram is an overall profile of antimicrobial susceptibility testing results of a specific microorganism to a battery of antimicrobial drugs. This profile is generated by the laboratory using aggregate data from a hospital or healthcare system; data are summarized periodically and presented showing percentages of organisms tested that are susceptible to a particular antimicrobial drug

次要结局

  • to prevent dental implant failure by setting the most suitable antibiotic regimen according to the intra-oral micro-organisms(through the study completion, an average of one year.)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Salma Mohamed Essam El-din Osman

medical doctor

Assiut University

相似试验