The Hypothesis of Emotional Empathy Imbalance in Autism: Conscious and Non-conscious Processing of Emotional Faces
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 51
- 主要终点
- Age
研究概览
简要总结
Empathy imbalance hypothesis suggests that individuals with autism Spectrum Disorder (ASD) should have a deficit of cognitive empathy and a surfeit of emotional empathy. Considering that inconsistent amygdala reactivity to emotional faces might be ascribed to aberrant attention in ASD, the investigators hypothesized to investigate if there would be an imbalance between conscious and nonconscious emotional processing. This fMRI study recruited 26 youths and young adults with autism spectrum disorder and 25 matched controls, and measured their amygdala reactivity and functional connectivity in response to conscious and nonconscious (backward masked) perception of threatening faces.
Keywords: Autism Spectrum Disorder; amygdala reactivity; emotional processing; fMRI
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 13 Years 至 40 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of severity of Autism-Spectrum Disorders
排除标准
- •Neurological abnormalities,
- •A history of epilepsy or seizures, head trauma a
结局指标
主要结局
Age
时间窗: 1 minutes
Age in years
Anxiety scores
时间窗: 10 minutes
State-Trait Anxiety Inventory (STAI)
Severity of Austism-Spectrum Disorders
时间窗: 20 minutes
Autism-Spectrum Quotient (AQ)
Color identification task
时间窗: 10 minutes
During fMRI scanning, subjects watched emotional faces and performed the color identification task, in which they were asked to judge the color of each face (pseudo-colored in either red, yellow, or blue) and to indicate the answer by a keypad button press.
Detection task
时间窗: 10 minutes
Immediately after fMRI scanning, participants underwent the detection task, during which they were shown all of the stimuli again and alerted of the presence of fearful faces. The subjects were administered a forced-choice test under the same presentation conditions as those during scanning and asked to indicate whether they observed a fearful face or not.
fMRI response
时间窗: 10 minutes
During fMRI scanning, subjects watched emotional faces and performed the color identification task, in which they were asked to judge the color of each face (pseudo-colored in either red, yellow, or blue) and to indicate the answer by a keypad button press.
次要结局
未报告次要终点
研究者
Yawei Cheng
Professor
National Yang Ming Chiao Tung University