Quarter-Time Myocardial Perfusion SPECT
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 134
- 主要终点
- Image quality of quarter-time WBR images is equivalent/superior to full-time FBP
研究概览
简要总结
A new, innovative software image processing method, wide beam reconstruction (WBR), utilizes resolution recovery and incorporates Poisson noise-reduction into the reconstruction process of NM images. This method facilitates the reconstruction of low count density myocardial perfusion SPECT images. Preliminary research indicates that SPECT acquisition time consequently can be reduced by 60% (less than 5 minutes) for rest and by 75% (just over 3 minutes) for stress, while tomographic image quality is maintained, or even improved. Such a decrease in image acquisition time decreases patient discomfort during the tomographic acquisition, decreases the opportunity for patient motion, and improves laboratory efficiency.
详细描述
Standard full-time SPECT will be processed using FBP and compared to 3-minute stress and 5-minute rest scans processed with WBR. The following scan parameters will be evaluated: image quality; perfusion defect extent, severity, and reversibility; transient ischemic dilatation; left ventricular end-diastolic volume; left ventricular end-systolic volume; left ventricular ejection fraction; and regional wall motion and wall thickening abnormalities. These parameters will be assessed visually by experienced Nuclear physicians (at least 2 blinded readers) and quantitatively using several different commercially available software programs.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient is clinically stable
- •Patient is able to tolerate additional 8 minutes of scanning
- •Patient is willing to undergo additional 8 minutes of scanning
排除标准
- •Unstable patient
- •Non-consenting patient
结局指标
主要结局
Image quality of quarter-time WBR images is equivalent/superior to full-time FBP
时间窗: March 2008
次要结局
- Image quality of quarter-time WBR is equivalent/superior to half-time WBR(March 2008)