Tight Glycemic Control in Acute Exacerbations of COPD
试验速览
- 阶段
- 不适用
- 入组人数
- 84
- 主要终点
- mortality
研究概览
简要总结
Glucose control has been shown as an important and independent prognostic factor in several acute conditions in hospitalized patients, including Acute MI, stroke, cardiac surgery and in critical care units.
Patients with acute exacerbation of COPD (AECOPD)and diabetes treated with insulin had a longer in-patient stay and more frequent isolation of Gram negative bacteria from sputum than those without diabetes.Hyperglycemia (>11 mmol/l) on admission predicted failure of non-invasive ventilation and infectious pulmonary complications in patients admitted to the ICU with acute respiratory failure caused by severe AECOPD.
The primary goal of this study is to test the hypothesis that in AECOPD, tight glycemic control during hospital stay will improve outcome of hospitalization.
The secondary goal of this study is to test new ways in controlling patients in the internal medicine ward.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •current or past smokers (at least 20 py)
- •patient with COPD be ATS criteria
- •hospitalized with acute exacerbation, 2/3 criteria:1- worsening of SOB 2-change in sputum volume 3- change in sputum color
- •signed informed concent
排除标准
- •respiratory failure (pH<7.35 ו Pco2>60 )
- •pneumonia
- •pneumothorax
- •bronchiectasis
- •lung collapse
- •congestive heart failure
- •lung cancer
- •suspected pulmonary emboli
- •immune deficiency (acquired 0r congenital)
- •cystic fibrosis
- •post lung implantation
- •asthma/ non smokers
结局指标
主要结局
mortality
时间窗: one year
次要结局
- hospialization(one year)
研究者
Idit F Liberty
Dr Idit Liberty MD
Soroka University Medical Center