A Prospective Single-Arm Study of EEG-Based Neural Signal Decoding for Cognitive Function Preservation in Patients Undergoing Brain Tumor Surgery
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Mini-Mental State Examination (MMSE) Total Score
研究概览
简要总结
Brain tumors and their surgical treatment may impair cognitive function, affecting patients' quality of life. This prospective single-arm study aims to evaluate the feasibility and clinical utility of an EEG-based neural signal decoding strategy for cognitive function preservation in patients undergoing brain tumor surgery. Participants will undergo standardized neuropsychological assessments together with preoperative, intraoperative, and postoperative electrophysiological recordings. The study will investigate whether EEG-based neural decoding can improve objective cognitive function assessment and support individualized functional preservation during brain tumor surgery.
详细描述
This is a prospective, single-center, single-arm interventional study designed to investigate an EEG-based neural signal decoding strategy for higher-order cognitive function preservation in patients undergoing brain tumor surgery.
Eligible patients with brain tumors scheduled for surgical treatment will be enrolled. Participants will receive standardized neuropsychological assessments before and after surgery. High-density EEG recordings will be acquired during different stages of the perioperative period, including task-based and resting-state paradigms when applicable. Neural signal decoding methods will be used to extract cognitive-related electrophysiological features and evaluate their association with postoperative cognitive outcomes.
The primary objective is to evaluate the feasibility of EEG-based neural signal decoding for objective cognitive assessment and functional preservation during brain tumor surgery. Secondary objectives include exploring the relationship between electrophysiological biomarkers and neuropsychological performance, evaluating perioperative cognitive changes, and providing preliminary evidence for individualized cognitive protection strategies in brain tumor patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 years to 75 years.
- •Patients diagnosed with brain glioma and scheduled for surgical treatment.
- •Conscious and able to understand study procedures.
- •Able to complete neuropsychological assessments.
- •Willing to participate and provide written informed consent.
排除标准
- •Severe dysfunction of major organs (heart, lung, liver, or kidney).
- •Severe psychiatric disorders or cognitive impairment.
- •Severe language impairment preventing completion of study procedures.
- •Any other condition judged by the investigator to make participation inappropriate.
研究组 & 干预措施
EEG-Guided Cognitive Function Preservation
Participants undergoing brain tumor surgery will receive the EEG-based neural signal decoding strategy in addition to standard surgical management for individualized cognitive function preservation. Cognitive outcomes will be evaluated using standardized neuropsychological assessments.
干预措施: EEG-Based Neural Signal Decoding Strategy (Procedure)
结局指标
主要结局
Mini-Mental State Examination (MMSE) Total Score
时间窗: Baseline, postoperative 1 week, postoperative 1 month, and postoperative 3 months
Cognitive function assessed using the Mini-Mental State Examination (MMSE). The total score ranges from 0 to 30, with higher scores indicate better cognitive function.
Montreal Cognitive Assessment (MoCA) Total Score
时间窗: Baseline, postoperative 1 week, postoperative 1 month, and postoperative 3 months
Cognitive function assessed using the Montreal Cognitive Assessment (MoCA). The total score ranges from 0 to 30, with higher scores indicate better cognitive function.
次要结局
未报告次要终点
研究者
Bo Wang
Associate Chief Physician
Huanhu Hospital Affiliated to Tianjin Medical University