Scaffolding in AI-Empowered Cognitive Training Improves Outcomes in Cognitive Impairment: A Real-world Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 516
- 主要终点
- Change in general cognitive ability from baseline (week 1) to week 8
研究概览
简要总结
This retrospective study aimed to validate and compare two individualized, closed-loop, AI-driven computerized cognitive training programs with a conventional non-AI training program in a real-world clinical setting. Using objective tablet-recorded data from patients' prior treatment, participants were categorized into three groups according to the training recommendation strategy they actually received. Changes in global cognitive function and specific cognitive domains after 8 weeks of training were compared across groups to evaluate the association between different training strategies and cognitive outcomes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 45 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age ≥ 45 years;
- •a Montreal Cognitive Assessment (MoCA) score between 10 and 25;
- •were able to communicate in Mandarin.
排除标准
- •no completion of at least 8 weeks of training;
- •no engagement in training for ≥ 60 minutes per week;
- •diagnosis of depression or other psychiatric disorders;
- •diagnosis of systemic diseases, such as hepatic or renal dysfunction, endocrine disorders, or vitamin deficiencies.
结局指标
主要结局
Change in general cognitive ability from baseline (week 1) to week 8
时间窗: From baseline (week 1) to week 8
The general cognitive ability was assessed by the Cognitive Index, calculated from task performance scores. The CCT platforms recorded the Cognitive Index in real time on a daily basis. Weekly Cognitive Index values were computed as the mean of the daily scores recorded over each 7-day period. The change in Cognitive Index from baseline to week 8 is reported.
次要结局
- Changes in domain-specific cognitive ability from baseline (week 1) to week 8 across seven cognitive subdomains(From baseline (week 1) to week 8)