临床试验/NCT00531713

NCT00531713已完成4 期

Effect of T4-T3 Combination Therapy Versus T4 Monotherapy in Patients With Hypothyroidism,a Double Blind Randomized Cross-Over Study.

Copenhagen University Hospital at Herlev1 个研究点分布在 1 个国家目标入组 59 人开始时间: 2003年4月最近更新: 2007年9月19日

适应症

干预措施

试验速览

阶段: 4 期
状态: 已完成
发起方
入组人数: 59
试验地点: 1
主要终点: Selv-rating scales: SF-36, SCL -90-R, BDI

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

To compare the effect of T4-T3 combination therapy versus T4 monotherapy in patients with autoimmune hypothyroidism, on stable T4-substitution therapy

详细描述

double blind randomized cross-over study.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Crossover
主要目的: Treatment
盲法: Triple (Participant, Care Provider, Investigator)

入排标准

年龄范围: 18 Years 至 75 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Hypothyroidism, S-TSH> 20 at diagnosis,Anti-TPO >300 Normal TSH (0,4-4,0) for 6 months.

排除标准

•pregnant women
•Thyroid cancer
•T3 treatment
•Post-partum thyroiditis

研究组 & 干预措施

2

Active Comparator

20 microgram of T3 is given and 50 microgram of T4 is withdrawn

干预措施: Triiodothyronine (Drug)

结局指标

主要结局

Selv-rating scales: SF-36, SCL -90-R, BDI

时间窗: 3 month treating

次要结局

BMI, bioimpedance(3 month treament)

研究者

发起方

Copenhagen University Hospital at Herlev

申办方类型

Other

研究点 (1)

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