Effects of Rhythmic Auditory Stimulation on Movements in Individuals at Risk for Psychotic Onset and Schizophrenia Patients
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Motion analysis by using an eight-camera motion capture system (VICON; Oxford Metrics Group, Oxford, UK)
研究概览
简要总结
The purpose of this research is to examine effects of movement training with the aid of rhythmic auditory stimulation (RAS) on reducing severity of dyskinesia and bradykinesia in at-risk individuals and schizophrenia patients. The investigators hypothesize that training with the aid of RAS reduced severity of bradykinesia and dyskinesia in at-risk individuals as well as in schizophrenia patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 13 Years 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •for at-risk individuals are:
- •A score of or above 9 in the Chinese version of the 16-item Prodromal Questionnaire (CPQ-16), or a score of or above 8.18 in the Chinese version of Community Assessment of Psychic Experiences with 15 items (CAPE-C15), or a score of or above 17 in Schizotypal Personality Questionnaire-Brief (SPQ-B);
- •A score of or above 22 in the Hong Kong version of Montreal Cognitive Assessment (HK-MoCA) to ensure that they can understand instructions;
- •A score of or above 60 in the Chinese Version of Edinburgh Handedness Inventory to ensure that they are right-handed.
- •The age ≥ 13 years.
- •The inclusion criteria for healthy controls are:
- •A score below the cut-off score of CPQ-16, CAPE-C15, and SPQ-B;
- •A score of or above 22 in MoCA;
- •A score of or above 60 in the Chinese Version of Edinburgh Handedness Inventory;
- •No first-degree family members having a diagnosis of mental illnesses.
- •The age ≥ 13 years.
- •At-risk participants and healthy controls will be excluded if they have any neurological / musculoskeletal dysfunction that may affect their upper-limb movements.
- •For schizophrenia patients:
- •The inclusion criteria for schizophrenia patients are:
- •A diagnosis of schizophrenia without other psychiatric diseases;
- •Having stable psychotic symptoms;
- •A score of or above 22 in HK-MoCA;
- •A score of or above 60 in the Chinese Version of Edinburgh Handedness Inventory.
- •The age ≥ 18 years.
- •The inclusion criteria for healthy controls are:
- •A score below the cut-off score of CPQ-16, CAPE-C15, and SPQ-B;
- •A score of or above 22 in MoCA;
- •A score of or above 60 in the Chinese Version of Edinburgh Handedness Inventory;
- •No first-degree family members having a diagnosis of mental illnesses.
- •The age ≥ 18 years.
- •Patients and healthy controls will be excluded if they have any neurological / musculoskeletal dysfunction that may affect their upper-limb movements.
排除标准
- 未提供
研究组 & 干预措施
schizophrenia- RAS
Schizophrenia patients in the experimental group will undergo upper-limb movement training with the aid of rhythmic auditory stimulation (RAS).
干预措施: Rhythmic auditory stimulation (RAS) for schizophrenia patients (Behavioral)
schizophrenia- no RAS
Schizophrenia patients in the control group will receive upper-limb training without the aid of RAS.
干预措施: No RAS for schizophrenia patients (Behavioral)
at risk- RAS
At-risk individuals in the experimental group will undergo upper-limb movement training with the aid of RAS.
干预措施: RAS for at-risk individuals (Behavioral)
at risk- no RAS
At-risk individuals in the control group will receive upper-limb training without the aid of RAS.
干预措施: No RAS for at-risk individuals (Behavioral)
结局指标
主要结局
Motion analysis by using an eight-camera motion capture system (VICON; Oxford Metrics Group, Oxford, UK)
时间窗: Within one week right after the last session of the intervention
normalized movement time (representing severity of parkinsonism). Unit: second/mm
Motion analysis by using an eight-camera motion capture system (VICON; Oxford Metrics Group, Oxford, UK)
时间窗: Within one week right before the 1st session of the intervention
normalized movement time (representing severity of parkinsonism). Unit: second/mm
次要结局
未报告次要终点
研究者
Dr WANG Shumei
Assistant Professor
The Hong Kong Polytechnic University