DIAGNOSTIC VALUE OF ELECTROCARDIOGRAPHIC ST-T WAVE CHANGES IN LEAD aVL IN PATIENTS WITH CHRONIC STABLE ANGINA
试验速览
- 阶段
- 不适用
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Corelation between ecg finding and coronary angiography finding
研究概览
简要总结
The electrocardiogram (ECG) is a simple and non-invasive bedside diagnostic tool with a well-established role in the diagnosis of (CAD). Many studies have found that the admission of ECG provides important prognostic information in patients admitted with chest pain. For instance, T wave inversion in anterior or inferior location and or ST-segment depression has been associated with high incidence of CAD.
详细描述
The aim of the work will be directed to study the diagnostic value of electrocardiographic ST-T wave changes in lead aVL in patients with chronic stable angina
The ECG findings vary considerably, depending importantly on four major factors: (1) the duration of the ischemic process (acute versus evolving or chronic) ; (2) its extent (large versus small) ; (3) its topography (anterior versus inferior-posterior and right ventricular) ; (4) the presence of other underlying conditions (e.g. LBBB, WPW or pacemaker pattern) that can mask or alters the classic pattern.
The resting electrocardiogram is normal in approximately half of patients with chronic stable angina pectoris, and even patients with severe CAD may have a normal tracing at rest. A normal resting ECG suggesting a normal LV function and it is unusual finding in a patient with an extensive previous infarction.
The most common electrocardiographic abnormalities in patients with chronic CAD are non specific ST-Twave changes with or without abnormal Q waves. In addition to myocardial ischemia, other conditions that can produce ST-T wave abnormalities include LV hypertrophy or dilation, electrolyte abnormalities, neurogenic effects, and anti-arrhythmic drugs.
In patients with known CAD, however, the occurrence of ST-T wave abnormalities on the resting ECG may correlate with the severity of the underlying heart disease. This association may explain the adverse association of ST-Twave changes with prognosis of these patients. In contrast, a normal resting ECG is more favorable long-term prognostic sign in patients with suspected or definite CAD.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients admitted at the Alexandria university hospitals or referred from secondary hospitals with documented CAD as proved by non invasive tests
排除标准
- •Clinical situations that may result in secondary aVL lead T wave inversion and /or ST segment depression from analysis as Bundle branch block either left or right, aortic stenosis, left ventricular hypertrophy and strain and paced ventricular rhythms.
结局指标
主要结局
Corelation between ecg finding and coronary angiography finding
时间窗: 9 months
the value of t wave and st segment changes in correlation with the cornary angiographic findings
次要结局
未报告次要终点
研究者
Awad Youssef Awad Zeid
M.B,CH.B.
Alexandria University