Effect of Dexmedetomidine on Maintenance and Recovery of Cranial Aneurysm Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- incidence of coughing
研究概览
简要总结
Dexmedetomidine induces analgesic and sedative effects and is reported to decrease agitation during emergence after general anesthesia in various surgeries. For patients undergoing cranial aneurysm surgeries, a calm anesthesia and emergence is important. In this study, the investigatorstend to observe the effect of dexmedetomidine on maintenance and recovery of patients undergoing cranial aneurysm surgeries.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing cerebral aneurysm embolism under general anesthesia
排除标准
- •patients with bradycardia or atrioventricular heart block
- •patients with ASA(American Society of Anesthesiologists) status over 3
- •patients with body mass index(BMI)≥30kg/m2
- •patients with difficulty in communication
- •patients with ruptured aneurysm
- •patients suspected or proved to be pregnant
研究组 & 干预措施
nasal dexmedetomidine
dexmedetomidine is given nasally, saline is given intravenously
干预措施: nasal dexmedetomidine (Drug)
nasal dexmedetomidine
dexmedetomidine is given nasally, saline is given intravenously
干预措施: intravenous saline (Drug)
intravenous dexmedetomidine
saline is given nasally, dexmedetomidine is given intravenously
干预措施: Intravenous dexmedetomidine (Drug)
intravenous dexmedetomidine
saline is given nasally, dexmedetomidine is given intravenously
干预措施: nasal saline (Drug)
normal saline
saline is given nasally and intravenously
干预措施: intravenous saline (Drug)
normal saline
saline is given nasally and intravenously
干预措施: nasal saline (Drug)
结局指标
主要结局
incidence of coughing
时间窗: from end of infusing anesthetics to 2 minutes after extubation, averagely 30 minutes
次要结局
- time to response to verbal command(from end of infusing anesthetics to response to verbal command,averagely 20 minutes)
- Mini-mental state examination score(24 hours after surgery)
- blood glucose before and after aneurysm embolism(immediately before inserting coil and after finishing inserting coil,an average of 1 hour)
- score of coughing(from end of infusing anesthetics to 2 minutes after extubation, averagely 30 minutes)
- blood pressure before and after extubation(from end of infusing anesthetics to 2 minutes after extubation, averagely 30 minutes)
- blood lactate before and after aneurysm embolism(immediately before inserting coil and after finishing inserting coil,,an average of 1 hour)
- Ricker's agitation-sedation score(from end of infusing anesthetics to 2 minutes after extubation, averagely 30 minutes)
- time to extubation(from end of infusing anesthetics to extubation,averagely 28 minutes)
研究者
Zhihong LU
clinical professor
Air Force Military Medical University, China