NCT03870425已完成不适用
Distribution of Nutrient Derived Amino Acids and Anabolic Effect in Healthy Elderly Individuals
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Muscle protein synthesis
研究概览
简要总结
The project examines over several days how the distribution pattern of dietary protein stimulate and affect the protein turnover of important proteins in the aging perspective, such as skeletal muscle proteins.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 65 Years 至 80 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women
- •Between 65-80 years of age
排除标准
- •BMI above 30
- •Vegetarians
- •Diabetes or other metabolic diseases
- •Medical treatment which affects protein turnover
- •Gastro-intestinal diseases, reduced kidney or liver function, or chronic inflammation diseases
- •Elevated blood-pressure or signs of atherosclerosis
- •More than 5 hours of regular exercise each week
结局指标
主要结局
Muscle protein synthesis
时间窗: 3 days
Myofibrillar FSR measured by deuterated water technique, by which deuterium labeled alanine incorporation into myofibrillar muscle protein synthesis can be measured.
Net protein balance
时间窗: 10 hours
Whole body net protein balance measured during 10 hours acute study. Measured by the application of stable amino acid labeled phenylalanine and tyrosine tracers, by which the protein synthesis, phenylalanine oxidation and protein breakdown can be calculated.
次要结局
- Phenylalanine oxidation(10 hours)
- Protein synthesis(10 hours)
- Signaling pathways in skeletal muscle(10 hours)
- Protein breakdown(10 hours)
- D5-phenylalanine appearance(12 hours)
- Plasma insulin(12 hours)
- D5-phenylalanine incorporation(3 days)
- Muscle protein synthesis(10 hours)
研究者
Jakob Agergaard
PhD, Postdoc
Bispebjerg Hospital
研究点 (2)
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