Pediatric Hypertension Registry (PHREG)
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 179
- 试验地点
- 2
- 主要终点
- Blood pressure
研究概览
简要总结
Pediatric hypertension is increasingly common and is a precursor for adult cardiovascular and renal disease. But even during childhood, hypertension is associated with significant morbidity, including cognitive impairment and organ damage. However, the cause of pediatric hypertension, the response to treatment, and the mechanisms behind organ damage are incompletely understood. Due to these limitations, there are no first-line medications, and treatment is often inadequate. An improved comprehension of the course of pediatric hypertension could enhance clinical care. The goal of this proposal is to create a registry of patients with hypertension to better enable research into this important disease. This patient registry will enhance the investigators ability to quickly collect and analyze data for research studies.
详细描述
The investigators will include all subjects evaluated at the Brenner Children's Hospital Pediatric Nephrology clinic since January 1st, 2013 with a diagnosis of high blood pressure confirmed with three separate blood pressure measurements >=90th percentile for age, sex, and height, or >120/80 mmHg. The investigators will exclude patients whose initial evaluation occurred on or after their 18th birthday.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- — 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients at one of the following : Wake Forest Baptist Health Brenner Children's Hospital Pediatric Nephrology clinic Emory University Pediatric Nephrology
- •Diagnosis of hypertension confirmed with three separate blood pressure measurements
- •Diagnosis after January 2013
- •>90th percentile for age, sex, height, or >120/80.
排除标准
- •Patients whose initial evaluation occurred on or after their 18th birthday.
结局指标
主要结局
Blood pressure
时间窗: 10 years
Auscultated blood pressure measurements in clinic
Left ventricular hypertrophy
时间窗: 10 years
Left ventricular hypertrophy and other cardiac structural/function changes on echocardiograms
Albuminuria
时间窗: 10 years
Urinary albumin-to-creatinine (\>30 mg/g)
次要结局
- Ambulatory blood pressure(10 years)
- Renal function(10 years)
- Uric acid(10 years)