DuALS - A Cross-sectional Observational Study of Gait Patterns in Dual-task Conditions in Patients With Amyotrophic Lateral Sclerosis
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 60
- 主要终点
- Dual-task cost at Timed Up and Go performance
研究概览
简要总结
The investigators hypothesize a relevant impact of cognitive status over gait performance in patients with amyotrophic lateral sclerosis (ALS), contributing to poor mobility and representing a relevant risk for falls. The present observational, cross-sectional study on ambulatory patients with ALS will evaluate gait performance using different sets of dual-task conditions to demonstrate the importance of cognitive aspects in rehabilitation programs for these patients. The dual-task conditions to be assessed during gait performance will include: counting backwards by 3 (executive simple task); counting backwards by 7 (executive complex task); mnemonic recall of the Rey's Auditory Verbal Learning Test (RAVLT). Patients' performance will be compared with a group of healthy controls with similar age and sex distribution in order to highlight the specific effects of the disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Dual-task cost at Timed Up and Go performance
时间窗: Cross-sectional (baseline) evaluation
Percentage of variability of gait scores obtained at the Timed Up and Go (TUG) test (i.e., time in seconds) in dual-task vs. single-task conditions in ALS patients compared with healthy controls
Dual-task cost at 1-Minute Walking Test performance
时间窗: Cross-sectional (baseline) evaluation
Percentage of variability of gait scores obtained at the 1-Minute Walking Test (1minWT) (i.e., meters walked in one minute) in dual-task vs. single-task conditions in ALS patients compared with healthy controls
次要结局
- Executive complex task(Cross-sectional (baseline) evaluation)
- Muscle strength(Cross-sectional (baseline) evaluation)
- Executive simple task(Cross-sectional (baseline) evaluation)
- Walking velocity(Cross-sectional (baseline) evaluation)
- Mnemonic ability(Cross-sectional (baseline) evaluation)
- Functional disability(Cross-sectional (baseline) evaluation)
- Cognitive impairment(Cross-sectional (baseline) evaluation)
研究者
Prof. Massimo Filippi
MD, Professor
IRCCS San Raffaele