The effects of BCG-vaccination on the innate immune response and immunoparalysis in healthy volunteers. Two proof-of-principle studies. - Effects of BCG on immune response

niversitair Medisch Centrum Sint Radboud0 个研究点目标入组 20 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

暂无简介。

•- Use of any medication
•- History of BCG-vaccination
•- Vaccination other than BCG, within 3 months prior to study or within study period
•- Previous spontaneous vagal collapse
•- History of atrial or ventricular arrhythmia
•- (Family) history of myocardial infarction or stroke under the age of 65 years
•- Cardiac conduction abnormalities on the ECG consisting of a 2nd degree atrioventricular block or a complex bundle branch block
•- Hypertension (defined as RR systolic > 160 or RR diastolic > 90)
•- Hypotension (defined as RR systolic < 100 or RR diastolic < 50)
•- Renal impairment (defined as plasma creatinin >120 µmol/l)
•- Liver enzyme abnormalities or positive hepatitis serology
•- Medical history of any disease associated with immune deficiency
•- CRP > 20 mg/L, WBC > 12x109/L, or clinically significant acute illness, including infections, within 4 weeks before endotoxin administration
•- Participation in a drug trial or donation of blood 3 months prior to the LPS challenge
•- Use of recreational drugs within 21 days prior to experiment day
•- Recent hospital admission or surgery with general anaesthesia (<3 months)
•- Disagreement of participant with informing general practitioner of participation in this study

发起方

niversitair Medisch Centrum Sint Radboud