Impact of Angiotensin Converting Enzyme Activity on Exercise Training Sensitivity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 52
- 试验地点
- 1
- 主要终点
- Maximal systemic oxygen uptake
研究概览
简要总结
The phenotype based on the insertion/deletion (I/D) polymorphism of the human angiotensin converting enzyme (ACE) gene has been associated with individual training response. Briefly, intervention studies have demonstrated an 11-fold greater training-induced improvement in muscular endurance for ACE I/I homozygotes compared to ACE D/D homozygotes.
Importantly, the ACE I/D polymorphism causes large inter-individual differences in serum ACE activity. Because the ACE D/D genotype is characterized by high plasma ACE activity and potentially blunted endurance exercise training response, it appears likely that ACE inhibitors (ACEi) have the potential to improve the outcome of exercise training for ACE D/D homozygotes.
Thus, in the present study the investigators apply a randomized double-blind placebo-controlled longitudinal design to investigate whether pharmacological inhibition of ACE activity can amplify the exercise training response in healthy humans carrying either the ACE D/D or ACE I/I genotype.
The study hypothesis is that inhibition of ACE activity in healthy humans with the ACE D/D genotype will amplify the health beneficial effects of exercise training while this is not the case in ACE I/I homozygotes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
盲法说明
The present study is double-blinded with regard to ACE genotype and study medication and the blinding is kept until completion of the trial
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged 20-50 years
排除标准
- 未提供
研究组 & 干预措施
Enalapril treatment
干预措施: Enalapril (Drug)
Placebo treatment
干预措施: Placebo (Drug)
结局指标
主要结局
Maximal systemic oxygen uptake
时间窗: 20 minutes
Training-induced changes in maximal systemic oxygen uptake (L/min) is evaluated with an incremental maximal cycle protocol on a cycle ergometer
Skeletal muscle endurance
时间窗: 5 minutes
Training-induced changes in muscle endurance evaluated as changes in duration (sec) of a repetitive elbow-flexion exercise
次要结局
- Blood volume(20 minutes)
- Steady-state systemic oxygen uptake(10 minutes)
- Muscle strength(1 minute)
- Left ventricular (LV) mass(45 minutes)
- Skeletal muscle oxidative capacity(60 minutes)
- Mitochondrial biogenesis(60 minutes)
- Fat free mass(20 minutes)
- Body fat percentage(20 minutes)
- LV end-diastolic volume(45 minutes)
- Mean arterial pressure (MAP)(10 minutes)
- Fat mass(20 minutes)
- Endurance performance(15 minutes)
- LV mean wall thickness(45 minutes)
- LV stroke volume(45 minutes)
- LV ejection fraction(45 minutes)
研究者
Nikolai Nordsborg
Associate Professor
University of Copenhagen