Can Therapy Alter CNS Processing of Chronic Pain: A Longitudinal Study
试验速览
- 阶段
- 不适用
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Pain
研究概览
简要总结
The purpose of this study is to investigate whether a psycho-therapeutic approach, group Cognitive Behavioral Therapy (CBT) plus a relapse prevention program, Therapeutic Interactive Voice Response (TIVR), modifies the dysfunctional sensory, emotional, and cognitive neural circuitry associated with chronic pain.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •At least 12 months of muscular-skeletal, non-neuropathic pain
排除标准
- •Malignancy causing or influencing chronic pain
- •Radiation or chemotherapy, or metastatic cancer of any type
- •Reflex Sympathetic Dystrophy (RSD) and/or neuropathic pain
- •Neurological disorders such as epilepsy or stroke, or other medical conditions
- •Psychiatric disorders
- •Opioid medication use for pain management
- •Past year history of illicit drug use that can result in altered cognition
- •Pregnancy
- •Exceeding weight limit of the MRI scanner
- •Incompatible implants due to MRI safety
- •Awaiting pain related surgical procedure
- •Involved in pain-related litigation
研究组 & 干预措施
Group Cognitive Behavioral Therapy
Participants will undergo 11 weeks of group cognitive behavioral therapy (CBT) and a pre- and post-intervention MRI brain scan.
干预措施: Group Cognitive Behavioral Therapy (Behavioral)
Pain Education
Participants will receive 11 weeks of pain education and a pre- and post-intervention MRI brain scan.
干预措施: Pain Education (Behavioral)
Therapeutic Interactive Voice Response
Four months of therapeutic interactive voice response (TIVR).
干预措施: Therapeutic Interactive Voice Response (Behavioral)
No TIVR
Control - no intervention
干预措施: NO TIVR (Behavioral)
结局指标
主要结局
Pain
时间窗: Seven Months
次要结局
未报告次要终点
研究者
Magdalena Naylor, MD, PhD
Magdalena R. Naylor, MD, PhD
University of Vermont