Effect of Intravenous Infusion of Lidocaine on Patients Undergoing Radical Resection of Colorectal Tumors
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- the concentration of tumor micrometastasis markers were determined by ELISA
研究概览
简要总结
Colorectal cancer (CRC) is one of the most common malignant tumors in the world. Surgical resection is the main treatment option for colorectal cancer patients. Surgery may enhance or accelerate tumor recurrence and metastasis. Multiple factors in the tumor microenvironment play important roles in tumor recurrence and metastasis, and modulating the tumor microenvironment can inhibit disease progression. Lidocaine has been found to inhibit tumor growth in animal experiments.
详细描述
Lidocaine was applied in the operation of colorectal tumor patients, and the effect on the postoperative microenvironment and micrometastasis of the patients was observed by detecting the stress, immunity, vascular tumor regeneration, inflammation, etc. of the patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •colorectal tumor patients
排除标准
- •Weight <45kg and >100kg
- •Sensitivity or hypersensitivity to lidocaine
- •Second or third degree heart block
- •Severe heart failure (ejection fraction < 20%)
- •History of active rhythm disorder
- •Acute severe liver and kidney injury
- •History of uncontrolled seizures
- •History of acute porphyria.
研究组 & 干预措施
Lidocaine is used in radical resection of colorectal tumors.
Administer 1.5 mg/kg intravenously to the patient before induction of anesthesia, and continue to infuse 1.5 mg/kg/h during the operation until the end of the operation
干预措施: Administer 1.5 mg/kg intravenously to the patient before induction of anesthesia, and continue to infuse 1.5 mg/kg/h during the operation until the end of the operation (Drug)
结局指标
主要结局
the concentration of tumor micrometastasis markers were determined by ELISA
时间窗: 3 days after surgery
the concentration of tumor micrometastasis markers such as CK20 was determined by ELISA
次要结局
- the concentration of immune indexes were determined by ELISA(3 days after surgery)
- the concentration of inflammatory factor were determined by ELISA(3 days after surgery)
- the concentration of stress hormones were determined by ELISA(3 days after surgery)
- the concentration of angiogenesis factors were determined by ELISA(3 days after surgery)