Modification of Cognitive Processing Therapy (CPT-C) for Posttraumatic Stress Disorder (PTSD) and Alcohol Dependence (AD)
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 9
- 试验地点
- 1
- 主要终点
- Alcohol use, PTSD symptoms
研究概览
简要总结
Objective: To develop a detailed treatment manual that modifies the existing CPT-C treatment protocol to allow for concurrent treatment of PTSD and AD, and to obtain some pilot data regarding its efficacy.
Hypothesis: We predict that CPT-C will significantly reduce the number of drinking days (measured by the Timeline Follow Back Method [TLFB]) and reduce the symptoms of PTSD (measured by the [CAPS and PCL] scores).
Design: This is a non-randomized, prospective study in which all participants will receive the modified CPT-C for 12 weeks by trained CPT-C clinicians, with each session lasting approximately 1-1.5 hours). Modifications to CPT-C include psychoeducation about alcohol use as an avoidance of PTSD symptoms integrated throughout treatment, integration of coping skills training for AD, weekly breathalyzer tests to measure blood alcohol level, and use and collection of daily dairies of alcohol use.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Males and females between the ages of 21-65 years old.
- •Current alcohol dependence as determined by the Structured Clinical Interview for DSM-IV Axis I Disorder (SCID; First et al. 1996). Abstinence no more than past 29 days. Primary substance dependence diagnosis of alcohol dependence.
- •Current PTSD as determined by the Clinician Administered PTSD Scale for DSM-IV(CAPS; Blake et al. 1995).
- •Participants on psychiatric medication must be on a stable regimen for at least 2 weeks before treatment begins.
- •Ability to participate psychologically and physically, able to give informed consent and complete assessments, and participate in study procedures.
排除标准
- •Current psychotic disorders
- •Current suicidal or homicidal ideations
- •Current substance dependence other than alcohol or nicotine dependence
- •Legal charges pending with potential of incarceration
- •Unstable serious medical conditions or one requiring acute medical treatments or anticipation of hospitalization for extended care
研究组 & 干预措施
1
modified CPT-C
干预措施: modified CPT-C (Other)
结局指标
主要结局
Alcohol use, PTSD symptoms
时间窗: 16 weeks
次要结局
- quality of life(16 weeks)