跳至主要内容
临床试验/NCT00144001
NCT00144001已完成不适用

Appropriateness of Antiepileptic Drug Use for Older Veterans

US Department of Veterans Affairs2 个研究点 分布在 1 个国家目标入组 9,682 人开始时间: 2000年10月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
9,682
试验地点
2
主要终点
Type of Antiepileptic drug prescribed for individuals with new onset epilepsy

研究概览

简要总结

Nearly 2% of veterans >65 are actively treated for epilepsy, and the incidence is projected to increase with the aging of our society. Since commonly used antiepileptic drugs are considered suboptimal for older patients, it is important to understand existing patterns of treatment for older veterans with epilepsy.

详细描述

OBJECTIVE(S):

  1. Identify patient, provider, and system factors predicting adoption of recommended AEDs for treatment of newly diagnosed older veterans (FY00-04).
  2. Identify barriers to use of recommended AED in initial therapy for newly diagnosed older veterans with epilepsy.
  3. Assess and compare effectiveness of long-term use of various AED.

METHODS:

Using existing national VA outpatient, inpatient, and pharmacy databases in conjunction with Medicare inpatient and outpatient standard analytic files, the 1999 National Health Survey of VA Enrollees, American Hospital Association data, and primary data collection, we will identify the extent to which treatment for older veterans newly diagnosed with epilepsy changed between FY00-FY04, and identify predictors of change at the patient, provider, and system levels. We will begin to identify barriers to use of recommended AED using structured interviews with primary care and general neurology providers in sites with high and low use of suboptimal AEDs in incident cases. Finally, we will compare hospitalizations, emergency room visits, and fall-related injuries (including fractures) for patients on different AED regimens.

RESULTS:

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
66 Years 至 —(Older Adult)
性别
All
接受健康志愿者

入选标准

  • Veterans 66 years and older receiving care from the Veterans Health Administration between fiscal years 2000-2004 Diagnosis of epilepsy and receiving anticonvulsant drugs

排除标准

  • No VA pharmacy data the year prior to epilepsy diagnosis

结局指标

主要结局

Type of Antiepileptic drug prescribed for individuals with new onset epilepsy

时间窗: Within one year of first epilepsy diagnosis

次要结局

未报告次要终点

研究者

申办方类型
Fed
责任方
Sponsor

研究点 (2)

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