A Feasibility Study of a Low Tidal Volume Ventilation Strategy in One Lung Ventilation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Radiological evidence of injury to the ventilated lung
研究概览
简要总结
A study of two ventilatory strategies for low tidal volume ventilation compared to a control group to elucidate if low tidal volumes of 3ml/kg or 4ml/kg were feasible for one lung ventilation.
详细描述
This study investigated the feasibility of low tidal volume ventilation for one lung ventilation.
45 patients were recruited - 15 patients in each of three groups, 3ml/kg, 4ml/kg or usual care.
Outcomes studied were length of stay, 30 day mortality, unplanned ICU admission, evidence of respiratory failure or requirement for non-invasive ventilation, chest x-ray infiltrates and requirement for antibiotics.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
盲法说明
open label, randomisation blinded
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •ASA I-III lung resection surgery requiring one lung ventilation
排除标准
- •ASA IV or above under 18 or over 80 years of age pregnancy previous lung lobectomy or pneumonectomy requirement for massive transfusion during the case BMI > 35
研究组 & 干预措施
3ml/kg
15 patients ventilated with 3ml/kg ideal body weight while on one lung ventilation
干预措施: tidal volume ventilation (Procedure)
4ml/kg
15 patients ventilated with 4ml/kg ideal body weight while on one lung ventilation
干预措施: tidal volume ventilation (Procedure)
control
15 patients ventilated using the anaesthetists usual ventilation strategy
干预措施: tidal volume ventilation (Procedure)
结局指标
主要结局
Radiological evidence of injury to the ventilated lung
时间窗: post operatively up to 6 weeks post operatively
evidence of infiltrates in the non operative lung
unplanned ICU admission
时间窗: up to 6 weeks post operatively
unplanned admission to the icu with respiratory issues
Requirement for non-invasive ventilation
时间窗: up to 6 weeks post operatively
whether a patient in the trial requires niv for respiratory failure
Hospital acquired pneumonia
时间窗: up to discharge at 6 weeks post operatively
pneumonia acquired in hospital
次要结局
- length of hospital stay(until patient discharge at 6 weeks post operatively)
- length of icu stay(until patient discharge at 6 weeks post operatively)
- 30 day mortality(30 days post operatively)
研究者
ignacio martin loeches
Consultant Intensivist
University of Dublin, Trinity College