Randomized control trial of vitamin D supplementation on surrogate markers of ageing (leukocyte telomerase length and telomerase activity), association/interactions with selected ageing-related genes (including myostatin, Î±-Actinin-3, vitamin D receptor, Forkhead box O3 and Sirtuin1), glycemic and metabolic markers in north Indian Individuals with the prediabetes

Indian Councial of Medical Research0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

试验速览

暂无简介。

•Cross-sectional Study:
•Inclusion Criteria: Individuals with prediabetes, aged 20-60 years.
•Prospective Intervention Study:
•Design: Randomized open labeled placebo-controlled trial.
•Inclusion Criteria:
•1.Pre-diabetes:
•a.Fasting blood glucose >=100mg/dl and <125.99mg/dl, or
•b.2-h plasma glucose >=140mg/dl and <200mg/dl (after ingestion of 75 g anhydrous oral glucose), and
•2.Baseline blood level of 25 hydroxy vitamin D <30ng/dl.
•3.Aged 20-60 years

•Cross sectional
•Exclusion Criteria:
•1.Received Vitamin D or calcium supplementation in the previous six months.
•2.On any medication within last one month which could potentially influence insulin secretion, insulin sensitivity, vitamin D or calcium metabolism and on any medication that activate steroid and xenobiotic receptors, and drugs used in transplantation.
•3.Severe end organ damage or chronic diseases: renal/hepatic failure, any malignancy, major systemic illness etc.
•4.Known case of diabetes mellitus, HIV infection and other endocrine disorders.
•Prospective Study
•1.Received Vitamin D and/or calcium supplementation in the previous six months.
•2.On any medication within last one month which could potentially influence insulin secretion, insulin sensitivity, vitamin D or calcium metabolism (e.g. metformin, thiazolidinediones, steroids etc) and on any medication that activate steroid and xenobiotic receptor and drugs used in transplantation (e.g. steroids, calcitonin etc.)
•3.Severe end organ damage or chronic diseases: renal/ hepatic failure, any malignancy, nephrotic syndrome, malabsorption etc.
•4.Known case of HIV infection.
•5.Primary or tertiary hyperparathyroidism, granulomatous disorders (e.g. sarcoidosis) and any lymphomas.
•6.Known case of diabetes mellitus.

发起方

Indian Councial of Medical Research