The NutriNet-Santé Study. A Web-based Prospective Cohort Study of the Relationship Between Nutrition and Health and of Dietary Patterns and Nutritional Status Predictors
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 170,000
- 试验地点
- 1
- 主要终点
- rheumatoid arthritis using health questionnaire and/or the website for declaration of major health events
研究概览
简要总结
The NutriNet-Santé study was set up to investigate nutrition and health relationships. Specifically, it was the first web-based cohort worldwide on such a large scale (n=171 000 as of 2021) focused on the complex link between nutrition and health status. It is characterized by a very detailed assessment of nutritional exposure and dietary behavior.
https://etude-nutrinet-sante.fr/ https://info.etude-nutrinet-sante.fr/en
详细描述
NutriNet-Santé is a large-scale (n=171,000) web-based cohort coordinated by EREN, launched in France in 2009 to investigate nutrition and health relationships. All required ethics authorisations have been obtained (listed here). NutriNet-Santé participants regularly fill questionnaires through a dedicated and secure website, providing extensive, high-quality nutritional and non-nutritional data, including repeated data on socio-demographics and lifestyle (yearly), anthropometrics (every 6 months), dietary intake (every 6 months), physical activity (IPAQ questionnaire, yearly)5 and health status (every 6 months). NutriNet-Santé is characterised by a very detailed and up-to-date assessment of nutritional exposure and dietary behaviours. Usual dietary intakes are assessed at baseline and every 6 months thereafter through a series of 3 non-consecutive randomly assigned 24h dietary records. Daily energy, alcohol, micro- and macronutrient intakes are calculated using the published NutriNet-Santé food composition database (>3,500 generic items). All major health events (e.g., cancers, cardio- and cerebrovascular diseases) are reported by the participants and validated by an expert committee of physicians based on medical records, and/or retrieved from the French National Health Insurance medico-administrative databases to limit potential reporting bias. In turn, mortality data are obtained from the exhaustive French National Mortality Registry (CépiDC). The number of incident events already registered is as follows: 4,200 cancers and 1,240 deaths. A sub-sample of the cohort (n=20,000) provided blood and urine samples, currently stored at -80°C in EREN's biobank.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 15 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •aged over 15 years
- •access to internet
排除标准
- •aged under 15 years
结局指标
主要结局
rheumatoid arthritis using health questionnaire and/or the website for declaration of major health events
时间窗: every 6 months after registration, up to 10 years of follow-up
self reported
Weight using anthropometric questionnaire
时间窗: every year after registration, up to 10 years of follow-up
self reported
Height using anthropometric questionnaire
时间窗: every year after registration, up to 10 years of follow-up
self reported
CVD using health questionnaire and/or the dedicated website for declaration of major health events
时间窗: every 6 months after registration, up to 10 years of follow-up
self reported
type 2 diabetes using health questionnaire and/or the website for declaration of major health events
时间窗: every 6 months after registration, up to 10 years of follow-up
self reported
migraine using health questionnaire and/or the website for declaration of major health events
时间窗: every 6 months after registration, up to 10 years of follow-up
self reported
cancers using health questionnaire and/or the website for declaration of major health events
时间窗: every 6 months after registration, up to 10 years of follow-up
self reported
depression using health questionnaire and/or the website for declaration of major health events
时间窗: every 6 months after registration, up to 10 years of follow-up
self reported
quality of life using the SF-36 questionnaire
时间窗: every 6 months after registration, up to 10 years of follow-up
self reported
Mortality
时间窗: continuously updated
CepiDC exhaustive national registry
SARSCOV-2 (Covid 19) infection
时间窗: regular update for a subsampe of the cohort from 2020
serology + questionnaires on symptoms
hypertension using health questionnaire and/or the website for declaration of major health events
时间窗: every 6 months after registration, up to 10 years of follow-up
self reported
metabolic syndrome using health questionnaire and/or the website for declaration of major health events
时间窗: every 6 months after registration, up to 10 years of follow-up
self reported
cognitive decline using health questionnaire and/or the website for declaration of major health events
时间窗: every 6 months after registration, up to 10 years of follow-up
self reported
multi-morbidity (mental and physical health)
时间窗: continuous update
combination of previsously listed mental and physical health outcomes
Mental health (incl. anxious disorders, sleep disorders, addictive behaviors, eating disorders)
时间窗: repeatedly during followup
self reported though validated scales and/or questionnaires
次要结局
未报告次要终点
研究者
Mathilde Touvier
Dr
University of Paris 13