The Effect of a Stress Reduction Program Using Mindfulness Techniques on Markers of Cellular Stress and Aging
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Salivary telomere length
研究概览
简要总结
The purpose of this research study is to examine whether a stress reduction intervention can improve health, mood and biological markers of cellular stress and aging in a group of chronically-stressed maternal caregivers and healthy maternal controls.
详细描述
This stress-reduction intervention was added into an ongoing observational study in May of 2013. The parent study is a prospective cohort study of the effects of chronic stress in a group of maternal caregivers with children on the autism spectrum and healthy controls whose children have no diagnosis. Study participants are being invited to enroll in a 12-week stress reduction course based on the principles of mindfulness. They will attend four six-hour workshops and participate in 12 weekly hour-long web video conferencing calls to reinforce what is taught in the workshops.
At the beginning and the end of the intervention, they complete self-report measures of psychological well-being and give saliva samples. Since the women are also participating in the longitudinal study, we have other before and after data for them. These include psycho-social measures, body measurements, psycho-physiology measurements, cognitive tests, actigraphy (for sleep), as well as saliva (for hormones), hair (for hormones) and blood (for telomeres, telomerase, gene expression, circulating hormones, inflammation and oxidative stress).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Must have at least one child between 2 and 16 at time of enrollment
- •Caregivers must have a child diagnosed in that age range diagnosed with an autism spectrum disorder.
- •Controls must have a healthy child in that age range. All women must be
排除标准
- •Chronic disease, including recent history of cancer
- •History of psychiatric disorder, such as bipolar disorder or post-traumatic stress disorder
- •Medications, including statins, anti-anxiety drugs, and for controls only anti-depressants.
研究组 & 干预措施
Stress-reduction class
Study participants enrolled in a 12-week stress reduction course based on the principles of mindfulness. They attended four six-hour workshops and participated in 12 weekly hour-long web video conferencing calls to reinforce what was taught in the workshops. We have two groups: chronically-stressed maternal caregivers of children on the autism spectrum and control mothers whose children have no significant psychiatric or physical impairment.
干预措施: Stress-reduction class (Behavioral)
结局指标
主要结局
Salivary telomere length
时间窗: Change from beginning to end of 12-week intervention
Participants will give saliva samples at the beginning and the end of the intervention. Salivary telomere length will be analyzed at both time points.
次要结局
- Telomere length from blood cells(Change over six months pre- and post-intervention)
- Psychological Well-Being(Change from beginning to end of 12-week intervention)
- Telomerase(Change over 6 months pre- and post-intervention)
- Cognitive functioning(Change over six months pre- and post-intervention)